315210-31-2
Chemical Structure
MAO-A/B-IN-3
- CAS No.: 315210-31-2
- Formula:C17H16N4O2
- Molecular Weight:308.33
InChIKey: XOAWGZIOUWWKFH-XDHOZWIPSA-N
SMILES: O=C(N/N=C(C1=CC=C(O)C=C1)\C)CN(C=N2)C3=C2C=CC=C3
Biological Activity: MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC50 values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases[1].
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MAO-A/B-IN-3 | MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC50 values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases. | |||||||||||||||||||||
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Keywords
