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primary+metabolite

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37

Inhibitors & Agonists

9

Natural
Products

8

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1178
    Cotinine
    3 Publications Verification

    (-)-Cotinine; (S)-Cotinine; NIH-10498

    		 Endogenous Metabolite nAChR Cardiovascular Disease Inflammation/Immunology
    Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .
    Cotinine
  • HY-N1867
    trans-Cinnamyl alcohol

    		PPAR Metabolic Disease
    trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .
    trans-Cinnamyl alcohol
  • HY-135582
    Raloxifene 4'-glucuronide

    		Estrogen Receptor/ERR Endocrinology
    Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
    Raloxifene 4'-glucuronide
  • HY-108229
    6β-Naltrexol

    6β-Hydroxynaltrexone

    		 Drug Metabolite Opioid Receptor Neurological Disease
    6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit .
    6β-Naltrexol
  • HY-137397
    8-Hydroxyefavirenz

    8-OH-EFV

    		 Apoptosis JNK Cancer
    8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer . 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    8-Hydroxyefavirenz
  • HY-108229S
    6β-Naltrexol-d3

    6β-Hydroxynaltrexone-d3

    		 Isotope-Labeled Compounds Opioid Receptor Drug Metabolite Neurological Disease
    6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit .
    6β-Naltrexol-d3
  • HY-131479
    Threo-dihydrobupropion hydrochloride

    		Drug Metabolite Neurological Disease
    Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry .
    Threo-dihydrobupropion hydrochloride
  • HY-W060470
    1-Methyl-4-imidazoleacetic acid hydrochloride

    		Histamine Receptor Neurological Disease
    1-Methyl-4-imidazoleacetic acid hydrochloride is a stable metabolite of Histamine (HY-B1204) that is produced by the oxidation of the primary metabolite, N-methylhistamine .
    1-Methyl-4-imidazoleacetic acid hydrochloride
  • HY-17528
    Cyhalofop

    Cyhalofop acid

    		 Drug Metabolite Others
    Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture .
    Cyhalofop
  • HY-A0178
    Isothipendyl

    AY 56012

    		 Histamine Receptor Endogenous Metabolite Inflammation/Immunology
    Isothipendyl (AY 56012), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist. Isothipendyl is a primary metabolite .
    Isothipendyl
  • HY-B1348
    Dimethadione

    		Drug Metabolite Neurological Disease
    Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal .
    Dimethadione
  • HY-131629
    N-Desmethyl-U-47700

    		Drug Metabolite Neurological Disease
    N-Desmethyl-U-47700 is the primary metabolite of U-47700 (an opioid agonist) .
    N-Desmethyl-U-47700
  • HY-100645
    Trimethoprim 3-oxide

    Trimethoprim 3-N-oxide

    		 Drug Metabolite Others
    Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim .
    Trimethoprim 3-oxide
  • HY-W008567
    N-Deschlorobenzoyl indomethacin

    		Drug Metabolite Others
    N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity .
    N-Deschlorobenzoyl indomethacin
  • HY-173391
    4-Hydroxy nonenal glutathione TFA

    4-HNE-GSH TFA

    		 Drug Metabolite Metabolic Disease
    4-Hydroxy nonenal glutathione (4-HNE-GSH) TFA is the primary metabolite of 4-Hydroxy-2-nonenal. 4-Hydroxy nonenal glutathionea TFA is a marker of oxidative stress in rat liver and hepatocytes. 4-Hydroxy nonenal glutathione TFA efficiently prevents formation of DNA adducts with 4-Hydroxy-2-nonenal in human cells .
    4-Hydroxy nonenal glutathione TFA
  • HY-33914
    4-Hydroxymethylpyrazole

    		Drug Metabolite Metabolic Disease
    4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876) produced through hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in both humans and monkeys, but its inhibition constant is significantly higher than that of Fomepizole, rendering its in vivo impact negligible .
    4-Hydroxymethylpyrazole
  • HY-A0178A
    Isothipendyl hydrochloride

    NSC 169186

    		 Endogenous Metabolite Histamine Receptor Inflammation/Immunology
    Isothipendyl hydrochloride (), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist.othipendyl is a primary metabolite .
    Isothipendyl hydrochloride
  • HY-W705371
    α-Hydroxy etizolam

    		Drug Metabolite GABA Receptor Others
    α-Hydroxy etizolam is the primary metabolite of Etizolam, possessing nearly identical pharmacological potency and high affinity for benzodiazepine receptors as Etizolam .
    α-Hydroxy etizolam
  • HY-Z6430
    Des-4-fluorobenzyl mosapride

    		5-HT Receptor Neurological Disease
    Des-4-fluorobenzyl mosapride is the primary metabolite of Mosapride (HY-B0189). Mosapride is an orally active gastroenterokinetic compound and is a 5HT4 agonist.
    Des-4-fluorobenzyl mosapride
  • HY-W750960R
    Biotinylated isoxazole (Standard)

    		Reference Standards Antibiotic Others
    Isothipendyl (hydrochloride) (Standard) is the analytical standard of Isothipendyl (hydrochloride). This product is intended for research and analytical applications. Isothipendyl hydrochloride (), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist.othipendyl is a primary metabolite .
    Biotinylated isoxazole (Standard)
  • HY-A0178AR
    Isothipendyl hydrochloride (Standard)

    NSC 169186 (Standard)

    		 Reference Standards Endogenous Metabolite Histamine Receptor Inflammation/Immunology
    Isothipendyl (hydrochloride) (Standard) is the analytical standard of Isothipendyl (hydrochloride). This product is intended for research and analytical applications. Isothipendyl hydrochloride (), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist.othipendyl is a primary metabolite .
    Isothipendyl hydrochloride (Standard)
  • HY-121385
    Hydroxy bosentan

    Ro 48-5033

    		 Endogenous Metabolite Cardiovascular Disease
    Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities .
    Hydroxy bosentan
  • HY-B1348R
    Dimethadione (Standard)

    		Reference Standards Drug Metabolite Neurological Disease
    Dimethadione (Standard) is the analytical standard of Dimethadione. This product is intended for research and analytical applications. Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal[1].
    Dimethadione (Standard)
  • HY-N1867R
    trans-Cinnamyl alcohol (Standard)

    		Reference Standards PPAR Metabolic Disease
    trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .
    trans-Cinnamyl alcohol (Standard)
  • HY-N6740R
    Beta-Zearalanol (Standard)

    		Reference Standards Apoptosis Metabolic Disease
    (±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .
    Beta-Zearalanol (Standard)
  • HY-121385S
    Hydroxy Bosentan-d6

    Ro 48-5033-d6

    		 Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    Hydroxy Bosentan-d6 is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities .
    Hydroxy Bosentan-d6
  • HY-17528R
    Cyhalofop (Standard)

    Cyhalofop acid (Standard)

    		 Drug Metabolite Reference Standards Others
    Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture .
    Cyhalofop (Standard)
  • HY-15876R
    Clopidogrel thiolactone (Standard)

    		Drug Metabolite Reference Standards P2Y Receptor Cardiovascular Disease
    Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture .
    Clopidogrel thiolactone (Standard)
  • HY-135581
    Raloxifene 6-glucuronide

    		Estrogen Receptor/ERR Endocrinology
    Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
    Raloxifene 6-glucuronide
  • HY-W706737
    N-Deschlorobenzoyl indomethacin-d3

    		Isotope-Labeled Compounds Drug Metabolite Others
    N-Deschlorobenzoyl indomethacin-d3 is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567). N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity .
    N-Deschlorobenzoyl indomethacin-d3
  • HY-135581S1
    Raloxifene 6-glucuronide-d4 lithium

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Endocrinology
    Raloxifene 6-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
    Raloxifene 6-glucuronide-d4 lithium
  • HY-135582S1
    Raloxifene 4'-glucuronide-d4 lithium

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Endocrinology
    Raloxifene 4'-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
    Raloxifene 4'-glucuronide-d4 lithium
  • HY-135582S
    Raloxifene 4'-glucuronide-d4

    		Estrogen Receptor/ERR Isotope-Labeled Compounds Endocrinology
    Raloxifene 4'-glucuronide-d4 is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
    Raloxifene 4'-glucuronide-d4
  • HY-W738587
    Threo-dihydrobupropion-d9 hydrochloride

    		Isotope-Labeled Compounds Drug Metabolite Neurological Disease
    rac-threo-Dihydro Bupropion Hydrochloride-d9 is the deuterium labeled Threo-dihydrobupropion hydrochloride (HY-131479). Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry .
    Threo-dihydrobupropion-d9 hydrochloride
  • HY-129240
    13-cis Acitretin

    Isoacitretin; Ro 13-7652

    		 Drug Derivative Others
    13-cis Acitretin (Isoacitretin; Ro 13-7652) is a retinoid and the major in vivo metabolite of etretinate. 13-cis Acitretin is formed via in vivo isomerization of etretinate. 13-cis Acitretin serves as the primary metabolite in blood .
    13-cis Acitretin
  • HY-121385S1
    Hydroxy Bosentan-d4

    Ro 48-5033-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    Hydroxy Bosentan-d4 is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities .
    Hydroxy Bosentan-d4
  • HY-33914R
    4-Hydroxymethylpyrazole (Standard)

    		Drug Metabolite Reference Standards Metabolic Disease
    4-Hydroxymethylpyrazole (Standard) is an analytical standard for 4-Hydroxymethylpyrazole (HY-33914). This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the primary metabolite of fomepizole (HY-B0876) via hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole inhibits alcohol dehydrogenase (ADH) in humans and monkeys, but the inhibition constant is much higher than that of fomepizole and is therefore negligible in vivo
    4-Hydroxymethylpyrazole (Standard)

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