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rat liver microsomal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) Acyltransferase (1) Apoptosis (1) Biochemical Assay Reagents (2) CD38 (1) COX (1) Drug Derivative (1) Endogenous Metabolite (1) Farnesyl Transferase (3) Fungal (2) HCV (1) HCV Protease (1) Isotope-Labeled Compounds (1) Lipoxygenase (1) Ras (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Stearoyl-CoA Desaturase (SCD) (2)
By Research Areas:	Cardiovascular Disease (7) Infection (3) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: LXR Microsomal Triglyceride Transfer Protein (MTP)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107410

SC-26196 4 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties .

HY-N4193

Glabrol 3 Publications Verification	Acyltransferase	Cardiovascular Disease
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-150508

MK-0159 1 Publications Verification	CD38	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC₅₀ values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD ⁺ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart .

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	COX Lipoxygenase Apoptosis	Cardiovascular Disease Inflammation/Immunology
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

HY-100299A

RPR107393	Farnesyl Transferase	Cardiovascular Disease Metabolic Disease
RPR107393 is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 inhibits rat liver microsomal squalene synthase with an IC₅₀ value of 0.8 nM. RPR107393 reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 reduces plasma cholesterol in rats and marmosets. RPR107393 can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis .

HY-100299

RPR107393 free base	Farnesyl Transferase	Cardiovascular Disease Metabolic Disease
RPR107393 free base is an orally active potent selective squalene synthase (SQS) inhibitor. RPR107393 free base inhibits rat liver microsomal squalene synthase with an IC₅₀ value of 0.8 nM. RPR107393 free base reduces triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. RPR107393 free base reduces plasma cholesterol in rats and marmosets. RPR107393 free base can be used for metabolic disease research, such as hypercholesterolemia, hypertriglyceridemia and atherosclerosis ^[1][2].

HY-113587

Nicoclonate hydrochloride Nicoclonol hydrochloride	Others	Others
Nicoclonate (hydrochloride)(Nicoclonol (hydrochloride)) is an antilipemic agent .

HY-177148

G256	Biochemical Assay Reagents	Cardiovascular Disease
G256 (Compound 1) is an amidinohydrazone. G256 can also be considered as a Schiff’s base of aminoguanidine. G256 exhibits antiarrhythmic activity. G256 is the reduced form of NOH-G256 by microsomal enzyme preparation from rabbit and rat liver homogenates in the presence of NADPH and NADH .

HY-177148A

G256 dihydrochloride	Biochemical Assay Reagents	Cardiovascular Disease
G256 (Compound 1) (dihydrochloride) is an amidinohydrazone. G256 (dihydrochloride) can also be considered as a Schiff’s base of aminoguanidine. G256 (dihydrochloride) exhibits antiarrhythmic activity. G256 (dihydrochloride) is the reduced form of NOH-G256 by microsomal enzyme preparation from rabbit and rat liver homogenates in the presence of NADPH and NADH .

HY-B0847S1

Propiconazole-d3 nitrate	Fungal Reactive Oxygen Species (ROS)	Infection
Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-B0847S

Propiconazole-d7	Isotope-Labeled Compounds Fungal Reactive Oxygen Species (ROS)	Infection
Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS) .

HY-W755367

Methyl glycyrrhetinate	11β-HSD	Others
Methyl glycyrrhetinate, a 18β-glycyrrhetinic acid analogue, is a dual inhibitor of 11β-HSD1 and 11β-HSD2 .

HY-107410R

SC-26196 (Standard)	Reference Standards Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
SC-26196 (Standard) is the analytical standard of SC-26196 (HY-107410). This product is intended for research and analytical applications. SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties .

HY-115516

BI-1388	HCV HCV Protease Ras	Infection
BI-1388 is a macrocyclic acylsulfonamide-based HCV NS3-4A protease inhibitor. BI-1388 inhibits clinically relevant drug-resistant mutant strains (KRAS ^D168V gt 1b and KRAS ^R155K gt 1a) and exhibits high liver distribution. BI-1388 is applicable for the research of HCV infection .

HY-169872

17-Hydroxystearic acid	Endogenous Metabolite	Others
17-Hydroxystearic acid isolable from Torulopsis magnoliae fermentation oil. 17-Hydroxystearic acid is a saturated C₁₈ ω2-hydroxy fatty acid existing in D- and L-enantiomeric forms .

HY-105628

Prodilidine CI-427	Others	Neurological Disease Inflammation/Immunology
Prodilidine (CI-427) is an orally active, pyrrolidine-derived non-narcotic pain inhibitor. Prodilidine exerts analgesic activity against various nociceptive stimuli, and shows no antipyretic, anti-inflammatory or respiratory depressive effects. Prodilidine fails to inhibit withdrawal symptoms of addictive agents in monkeys, but exhibits excitatory effects and enhances the crossed extensor reflex at toxic doses. Prodilidine is well absorbed from the gastrointestinal tract and metabolized via hepatic microsomal N-demethylation, displaying isomer-specific activity, toxicity and metabolic characteristics. Prodilidine can be used in research related to chronic pain (e.g., cancer-, musculoskeletal/arthritis-derived), traumatic pain and arthritic pain .

HY-N17448

Fraxinuacidoside	Drug Derivative	Others
Fraxinuacidoside functions as a norditerpene glucopyranoside with a unique carbon skeleton. Fraxinuacidoside can be found in the stem bark of Fraxinus sieboldiana .

Cat. No.	Product Name	Type

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	Biochemical Assay Reagents
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

trans-2-Nonenal

trans-2-Nonen-1-al

Biochemical Assay Reagents

trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4193

Glabrol 3 Publications Verification	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Acyltransferase
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	Source Classification	COX Lipoxygenase Apoptosis
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-169872

17-Hydroxystearic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite
17-Hydroxystearic acid isolable from Torulopsis magnoliae fermentation oil. 17-Hydroxystearic acid is a saturated C₁₈ ω2-hydroxy fatty acid existing in D- and L-enantiomeric forms .

HY-N17448

Fraxinuacidoside	Structural Classification Fraxinus sieboldiana Blume Oleaceae Plants Saccharides Monosaccharides Source Classification	Drug Derivative
Fraxinuacidoside functions as a norditerpene glucopyranoside with a unique carbon skeleton. Fraxinuacidoside can be found in the stem bark of Fraxinus sieboldiana .

Cat. No.	Product Name	Chemical Structure

HY-B0847S1

Propiconazole-d3 nitrate
Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

Propiconazole-d3 nitrate

Propiconazole-d₃ (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

HY-B0847S

Propiconazole-d7
Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS) .

Propiconazole-d7

Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS) .

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rat liver microsomal

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
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