Methyl glycyrrhetinate

Cat. No.: HY-W755367: Data Sheet Handling Instructions
FAQs
Technical Support

Methyl glycyrrhetinate, a 18β-glycyrrhetinic acid analogue, is a dual inhibitor of 11β-HSD1 and 11β-HSD2.

For research use only. We do not sell to patients.

Methyl glycyrrhetinate Chemical Structure

CAS No. : 1477-44-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Methyl glycyrrhetinate, a 18β-glycyrrhetinic acid analogue, is a dual inhibitor of 11β-HSD1 and 11β-HSD2^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	EC₅₀	>30 μM Compound: 5	Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
518A2	EC₅₀	30 μM Compound: 5	Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
518A2	IC₅₀	27.54 μM Compound: 1	Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay	[PMID: 20932766]
518A2	IC₅₀	27.54 μM Compound: GA-Me	Cytotoxicity against human 518A2 cells by SRB assay Cytotoxicity against human 518A2 cells by SRB assay	[PMID: 24361520]
518A2	IC₅₀	27.54 μmol Compound: 1	Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human 518A2 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
8505C	EC₅₀	>30 μM Compound: 5	Cytotoxicity against human 8505C cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human 8505C cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
8505C	IC₅₀	26.07 μM Compound: 1	Cytotoxicity against human 8505C cells after 96 hrs by SRB assay Cytotoxicity against human 8505C cells after 96 hrs by SRB assay	[PMID: 20932766]
8505C	IC₅₀	26.07 μM Compound: GA-Me	Cytotoxicity against human 8505C cells by SRB assay Cytotoxicity against human 8505C cells by SRB assay	[PMID: 24361520]
8505C	IC₅₀	26.07 μmol Compound: 1	Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human 8505C cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
A253 cell line	IC₅₀	19.42 μM Compound: 1	Cytotoxicity against human A253 cells after 96 hrs by SRB assay Cytotoxicity against human A253 cells after 96 hrs by SRB assay	[PMID: 20932766]
A253 cell line	IC₅₀	19.42 μM Compound: GA-Me	Cytotoxicity against human A253 cells by SRB assay Cytotoxicity against human A253 cells by SRB assay	[PMID: 24361520]
A253 cell line	IC₅₀	19.42 μmol Compound: 1	Cytotoxicity against human A253 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human A253 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
A2780	IC₅₀	25.54 μM Compound: 1	Cytotoxicity against human A2780 cells after 96 hrs by SRB assay Cytotoxicity against human A2780 cells after 96 hrs by SRB assay	[PMID: 20932766]
A2780	IC₅₀	25.54 μmol Compound: 1	Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human A2780 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
A-431	IC₅₀	25.28 μM Compound: 1	Cytotoxicity against human A431 cells after 96 hrs by SRB assay Cytotoxicity against human A431 cells after 96 hrs by SRB assay	[PMID: 20932766]
A549	EC₅₀	>30 μM Compound: 5	Cytotoxicity against human A549 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human A549 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
A549	IC₅₀	>100 μM Compound: GA-1	Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay	[PMID: 26343825]
A549	IC₅₀	23.5 μM Compound: 1	Cytotoxicity against human A549 cells after 96 hrs by SRB assay Cytotoxicity against human A549 cells after 96 hrs by SRB assay	[PMID: 20932766]
A549	IC₅₀	23.5 μmol Compound: 1	Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
DLD-1	IC₅₀	26.12 μM Compound: 1	Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay	[PMID: 20932766]
DLD-1	IC₅₀	26.12 μM Compound: GA-Me	Cytotoxicity against human DLD1 cells by SRB assay Cytotoxicity against human DLD1 cells by SRB assay	[PMID: 24361520]
DLD-1	IC₅₀	26.12 μmol Compound: 1	Cytotoxicity against human DLD1 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human DLD1 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
FaDu	IC₅₀	23.41 μM Compound: 1	Cytotoxicity against human FADU cells after 96 hrs by SRB assay Cytotoxicity against human FADU cells after 96 hrs by SRB assay	[PMID: 20932766]
FaDu	IC₅₀	23.41 μmol Compound: 1	Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human FADU cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
HCT-116	IC₅₀	22.1 μM Compound: 1	Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay Cytotoxicity against human HCT116 cells after 96 hrs by SRB assay	[PMID: 20932766]
HCT-116	IC₅₀	22.1 μmol Compound: 1	Cytotoxicity against human HCT116 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human HCT116 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
HCT-8	IC₅₀	24.36 μM Compound: 1	Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay Cytotoxicity against human HCT8 cells after 96 hrs by SRB assay	[PMID: 20932766]
HCT-8	IC₅₀	24.36 μmol Compound: 1	Cytotoxicity against human HCT8 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human HCT8 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
HeLa	IC₅₀	>100 μM Compound: GA-1	Antiproliferative activity against human HeLa cells after 48 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 48 hrs by CCK-8 assay	[PMID: 26343825]
HepG2 2.2.15	CC₅₀	>1744.29 μM Compound: 6	Cytotoxicity against human HepG2(2.2.15) cells Cytotoxicity against human HepG2(2.2.15) cells	[PMID: 22520261]
HepG2 2.2.15	IC₅₀	>1744.29 μM Compound: 6	Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B e-antigen release Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in hepatitis B e-antigen release	[PMID: 22520261]
HepG2 2.2.15	IC₅₀	>443.57 μM Compound: 6	Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA replication Antiviral activity against Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as reduction in viral DNA replication	[PMID: 22520261]
HT-29	EC₅₀	>30 μM Compound: 5	Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
HT-29	IC₅₀	27.54 μM Compound: 1	Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay	[PMID: 20932766]
HT-29	IC₅₀	27.54 μmol Compound: 1	Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
J774	IC₅₀	>100 μM Compound: 14	Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method	[PMID: 24268542]
KB 3-1	IC₅₀	>100 μM Compound: 14	Cytotoxicity against human KB-3-1 cells assessed as cell survival after 24 hrs by MTT assay Cytotoxicity against human KB-3-1 cells assessed as cell survival after 24 hrs by MTT assay	[PMID: 24268542]
MCF7	EC₅₀	>30 μM Compound: 5	Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
MCF7	IC₅₀	>100 μM Compound: GA-1	Antiproliferative activity against human MCF7 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human MCF7 cells after 48 hrs by CCK-8 assay	[PMID: 26343825]
MCF7	IC₅₀	22.14 μM Compound: 1	Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 20932766]
MCF7	IC₅₀	22.14 μM Compound: GA-Me	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 24361520]
MCF7	IC₅₀	22.14 μmol Compound: 1	Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
NIH3T3	IC₅₀	22.81 μM Compound: 1	Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay	[PMID: 20932766]
NIH3T3	IC₅₀	22.81 μM Compound: GA-Me	Cytotoxicity against mouse NIH/3T3 cells by SRB assay Cytotoxicity against mouse NIH/3T3 cells by SRB assay	[PMID: 24361520]
SW-1736	IC₅₀	34.87 μM Compound: 1	Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay	[PMID: 20932766]
SW-1736	IC₅₀	34.87 μM Compound: GA-Me	Cytotoxicity against human SW1736 cells by SRB assay Cytotoxicity against human SW1736 cells by SRB assay	[PMID: 24361520]
SW-1736	IC₅₀	34.87 μmol Compound: 1	Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human SW1736 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]
SW480	IC₅₀	16.08 μM Compound: 1	Cytotoxicity against human SW480 cells after 96 hrs by SRB assay Cytotoxicity against human SW480 cells after 96 hrs by SRB assay	[PMID: 20932766]
SW480	IC₅₀	16.08 μmol Compound: 1	Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assay Cytotoxicity against human SW480 cells after 96 hrs by sulforhodamine B assay	[PMID: 20884085]

In Vitro

Methyl glycyrrhetinate (compound 34) (10 μM) inhibits rat liver microsomal 11β-HSD1 and rat kidney microsomal 11β-HSD2, with 85% and 105% inhibition respectively at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

484.71

Formula

C₃₁H₄₈O₄

CAS No.

1477-44-7

SMILES

C[C@@]1(CC[C@]2([C@@]([H])(C1)C([C@]3(CC2)C)=CC([C@]4([C@]3(CC[C@@]5([C@@]4(CC[C@@H](C5(C)C)O)C)[H])C)[H])=O)C)C(OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Su X, et al. Novel 18beta-glycyrrhetinic acid analogues as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenases. Bioorg Med Chem. 2004;12(16):4439-4457. [Content Brief]