2. Disease Areas
  3. Neurological, Eye or Ear Disease Musculoskeletal Disease Inflammation or Immune System Disease
  4. Pain Arthritis
  5. Prodilidine

Prodilidine (CI-427) is an orally active, pyrrolidine-derived non-narcotic pain inhibitor. Prodilidine exerts analgesic activity against various nociceptive stimuli, and shows no antipyretic, anti-inflammatory or respiratory depressive effects. Prodilidine fails to inhibit withdrawal symptoms of addictive agents in monkeys, but exhibits excitatory effects and enhances the crossed extensor reflex at toxic doses. Prodilidine is well absorbed from the gastrointestinal tract and metabolized via hepatic microsomal N-demethylation, displaying isomer-specific activity, toxicity and metabolic characteristics. Prodilidine can be used in research related to chronic pain (e.g., cancer-, musculoskeletal/arthritis-derived), traumatic pain and arthritic pain.

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Prodilidine

Prodilidine Chemical Structure

CAS No. : 3734-17-6

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Prodilidine Related Antibodies

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Description

Prodilidine (CI-427) is an orally active, pyrrolidine-derived non-narcotic pain inhibitor. Prodilidine exerts analgesic activity against various nociceptive stimuli, and shows no antipyretic, anti-inflammatory or respiratory depressive effects. Prodilidine fails to inhibit withdrawal symptoms of addictive agents in monkeys, but exhibits excitatory effects and enhances the crossed extensor reflex at toxic doses. Prodilidine is well absorbed from the gastrointestinal tract and metabolized via hepatic microsomal N-demethylation, displaying isomer-specific activity, toxicity and metabolic characteristics. Prodilidine can be used in research related to chronic pain (e.g., cancer-, musculoskeletal/arthritis-derived), traumatic pain and arthritic pain[1][2][3].

In Vitro

Prodilidine undergoes N-demethylation via liver microsomes from multiple species, with the (-)-Prodilidine showing greater demethylation than the (+)-Prodilidine by rat liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Prodilidine Related Antibodies
In Vivo

Prodilidine hydrochloride (7.2-84.0 mg/kg; p.o.; s.c.; i.v.) exhibits analgesic activity in mice, with ED50 values ranging from 7.2 mg/kg (subcutaneous, writhing assay) to 84.0 mg/kg (oral, tail-pinch assay), and LD50 values ranging from 91 mg/kg (intravenous) to 318 mg/kg (oral)[1].
Prodilidine hydrochloride (11.2-17.8 mg/kg; p.o.; s.c.; i.v.) exhibits analgesic activity in rats, with ED50 values ranging from 11.2 mg/kg (intravenous) to 17.3 mg/kg (oral) in the tail-flick assay, and LD50 values ranging from 74 mg/kg (intravenous) to 253 mg/kg (oral)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 84.0 mg/kg (tail-pinch assay, p.o.); 72.3 mg/kg (tail-pinch assay, s.c.); 30.0 mg/kg (tail-pinch assay, i.v.); 7.2 mg/kg (writhing assay, s.c.); 318 mg/kg (LD50, p.o.); 194 mg/kg (LD50, s.c.); 91 mg/kg (LD50, i.v.)
Administration: p.o. (tail-pinch assay); s.c. (tail-pinch assay, writhing assay); i.v. (tail-pinch assay)
Result: Achieved an ED50 of 84.0 mg/kg orally in the tail-pinch assay.
Achieved an ED50 of 72.3 mg/kg subcutaneously in the tail-pinch assay.
Achieved an ED50 of 30.0 mg/kg intravenously in the tail-pinch assay.
Achieved an ED50 of 7.2 mg/kg subcutaneously in the writhing assay.
Reached an LD50 of 318 mg/kg orally in mice.
Reached an LD50 of 194 mg/kg subcutaneously in mice.
Reached an LD50 of 91 mg/kg intravenously in mice.
Molecular Weight

247.34

Formula

C15H21NO2
CAS No.
SMILES

O=C(OC1(C=2C=CC=CC2)CCN(C)C1C)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Prodilidine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prodilidine3734-17-6CI-427CI427CI 427Othersdogsmonkeysmicerat gastrointestinal tractsarthritic painrodentsliver microsomal N-demethylationspinal catschronic paintraumatic painInhibitorinhibitorinhibit

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