3734-17-6
Chemical Structure
Prodilidine
Synonym(s): CI-427
- CAS No.: 3734-17-6
- Formula:C15H21NO2
- Molecular Weight:247.34
IUPAC Name: 1,2-dimethyl-3-phenylpyrrolidin-3-yl propionate
InChIKey: LUKSBMJXPCFBKO-UHFFFAOYSA-N
SMILES: O=C(OC1(C=2C=CC=CC2)CCN(C)C1C)CC
Biological Activity: Prodilidine (CI-427) is an orally active, pyrrolidine-derived non-narcotic pain inhibitor. Prodilidine exerts analgesic activity against various nociceptive stimuli, and shows no antipyretic, anti-inflammatory or respiratory depressive effects. Prodilidine fails to inhibit withdrawal symptoms of addictive agents in monkeys, but exhibits excitatory effects and enhances the crossed extensor reflex at toxic doses. Prodilidine is well absorbed from the gastrointestinal tract and metabolized via hepatic microsomal N-demethylation, displaying isomer-specific activity, toxicity and metabolic characteristics. Prodilidine can be used in research related to chronic pain (e.g., cancer-, musculoskeletal/arthritis-derived), traumatic pain and arthritic pain[1][2][3].
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Prodilidine | Prodilidine (CI-427) is an orally active, pyrrolidine-derived non-narcotic pain inhibitor. Prodilidine exerts analgesic activity against various nociceptive stimuli, and shows no antipyretic, anti-inflammatory or respiratory depressive effects. Prodilidine fails to inhibit withdrawal symptoms of addictive agents in monkeys, but exhibits excitatory effects and enhances the crossed extensor reflex at toxic doses. Prodilidine is well absorbed from the gastrointestinal tract and metabolized via hepatic microsomal N-demethylation, displaying isomer-specific activity, toxicity and metabolic characteristics. Prodilidine can be used in research related to chronic pain (e.g., cancer-, musculoskeletal/arthritis-derived), traumatic pain and arthritic pain. | |||||||||||||||||||||
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- [1]. Eddy N B. Codeine and its alternates for pain and cough relief[J]. Annals of Internal Medicine, 1969, 71(6): 1209-1212.
- [2]. Kissel J W, et al. The pharmacology of prodilidine hydrochloride, a new analgetic agent[J]. The Journal of Pharmacology and Experimental Therapeutics, 1961, 134(3): 332-340.
- [3]. Winder C V, et al. Pharmacologic and toxicologic studies of m-(1-methyl-3-propyl-3-pyrrolidinyl) phenol (CI-572), an analgetic and antitussive agent[J]. The Journal of Pharmacology and Experimental Therapeutics, 1966, 154(1): 161-175.
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