1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. Glabrol

Glabrol 

Cat. No.: HY-N4193
Handling Instructions

Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity.

For research use only. We do not sell to patients.

Glabrol Chemical Structure

Glabrol Chemical Structure

CAS No. : 59870-65-4

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Description

Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1].

IC50 & Target[1]

ratACAT

24.6 μM (IC50)

In Vitro

Glabrol (Compound 1) decreases cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells[1].

Molecular Weight

392.49

Formula

C₂₅H₂₈O₄

CAS No.

59870-65-4

SMILES

O=C1C[[email protected]@H](C2=CC=C(O)C(C/C=C(C)\C)=C2)OC3=C(C/C=C(C)\C)C(O)=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

GlabrolAcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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