Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

  • Bioorg Med Chem Lett. 2014 Dec 15;24(24):5644-5647. doi: 10.1016/j.bmcl.2014.10.077.
Hunseung Yoo  1 ,  Hee-Sung Chae  2 ,  Young-Mi Kim  2 ,  Minseok Kang  3 ,  Keun Ho Ryu  3 ,  Hee Chul Ahn  2 ,  Kee Dong Yoon  4 ,  Young-Won Chin  2 ,  Jinwoong Kim  5
Affiliations
  • 1. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea; New Drug Preclinical & Analytical Team, Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, 463-400, Republic of Korea.
  • 2. College of Pharmacy and BK21 PLUS R-FIND Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang, Gyeonggi-do 410-820, Republic of Korea.
  • 3. New Drug Preclinical & Analytical Team, Life Science R&D Center, SK Chemicals, 310 Pangyo-ro, 463-400, Republic of Korea.
  • 4. College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 420-743, Republic of Korea.
  • 5. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: [email protected].
PMID: 25467151 DOI: 10.1016/j.bmcl.2014.10.077
Abstract

Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 μM, respectively.

Keywords
Anti-allergy; Arylbenzofruran; Flavonoid; Interleukin-6; Sophora tonkinensis.