susceptibility

By Targets:	Antibiotic (4) Bacterial (8) Biochemical Assay Reagents (1) Caspase (2) Cholinesterase (ChE) (1) DNA Stain (1) DNA/RNA Synthesis (1) Fungal (1) GABA Receptor (1) HCV (1) HIV Protease (1) Influenza Virus (1)
By Research Areas:	Cancer (4) Infection (12) Inflammation/Immunology (3) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008833

3-Aminobutanoic acid	Bacterial	Infection
3-Aminobutanoic acid is a β-amino acid. 3-Aminobutanoic acid can protect plant against a challenge infection with P. infestans. 3-Aminobutanoic acid has various levels of susceptibility for the pathogen .

HY-N0224

Epigoitrin	Influenza Virus	Infection Cancer
Epigoitrin is a natural alkaloid from Isatis tinctoria, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling .

HY-10393

Eperezolid PNU-100592	Bacterial Antibiotic	Infection
Eperezolid(PNU-100592) is a oxazolidinone antibacterial agent, Eperezolid demonstrated good in vitro inhibitory activity, regardless of methicillin susceptibility for staphylococci(MIC90= 1-4 mg/ml).

HY-P5860

MmTx1 toxin Micrurotoxin 1	GABA Receptor	Neurological Disease
MmTx1 toxin (Micrurotoxin 1) is an allosteric GABA_A receptor modulator that increases GABA_A receptor susceptibility to agonist .

HY-131204

CZL80	Caspase	Neurological Disease
CZL80, a brain-penetrable caspase-1 inhibitor with an IC₅₀ of 0.01 μM, could be used in the study of febrile seizures and later enhanced epileptogenic susceptibility .

HY-N4117

Hamamelitannin	Bacterial	Infection
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .

HY-126569

Efrotomycin	Antibiotic Bacterial	Infection
Efrotomycin is an orally active antibiotic. Efrotomycin can be isolated from the Streptomyces Lactamdurans. Efrotomycin has insignificant effect on Salmonella typhimurium quantity, duration, shedding rate, and antimicrobial susceptibility in infected pigs .

HY-149762

IMBI	Bacterial	Infection
IMBI (compound 32) is an antibacterial agent that inhibits quorum sensing (QS) against drug-resistant pathogens. IMBI inhibits biofilm formation of Salmonella marcescens and restores or increases its susceptibility to antimicrobial drugs .

HY-153068

CZL55

Caspase Inflammation/Immunology

CZL55 is a caspase-1 inhibitor with an IC₅₀ value of 24 nM. CZL55 can be used for the research of febrile seizures (FS) .

CZL55	Caspase	Inflammation/Immunology
CZL55 is a caspase-1 inhibitor with an IC₅₀ value of 24 nM. CZL55 can be used for the research of febrile seizures (FS) .

HY-B1278B

(±)-α-Tocopherol acetate (±)-Vitamin E acetate	Biochemical Assay Reagents	Infection
(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .

HY-N7382

Laburnetin	Bacterial	Infection
Laburnetin is a kind of isoflavone antibacterial agent. Laburnetin has antibacterial activity against fungi and S. vesicarium. Laburnetin intensifies the susceptibility of Methicillin (HY-121544) resistant Staphylococcus aureus (MRSA) strains to Methicillin. Laburnetin can be used to control pests of cultivated species .

HY-155011

MB076	Others	Others
MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with K_i values ＜ 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility .

HY-13234

Rifaximin 1 Publications Verification	Bacterial Antibiotic DNA/RNA Synthesis	Infection Cancer
Rifaximin, a gastrointestinal-selective antibiotic, binds the β-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of bacterial RNA synthesis. Rifaximin susceptibility is higher against Gram-positive strains (MIC: 0.03-5 mg/ml) compared to Gram-negative bacteria (MIC: 8-50 mg/mL) .

HY-D1571

CellTracker Blue CMF2HC Dye	DNA Stain	Others
CellTracker Blue CMF2HC Dye is a blue dye, can be used in two-channel nuclei acid sequencing, with blue and purple excitation light (450-460 nm/400-405nm or 415-450 nm/480-525nm). CellTracker Blue CMF2HC Dye can be used to rapid determination of antibiotic sensitivity of microorganisms .

HY-B0815S

Chlorpyrifos-d10	Cholinesterase (ChE)	Neurological Disease
Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-P1934

Cyclo(Phe-Pro) 4 Publications Verification Cyclo(phenylalanylprolyl); A-64863	HCV	Infection
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses .

HY-107123

TMC310911 ASC-09	HIV Protease	Infection
TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC₅₀ values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity .

HY-N7432

DIMBOA	Antibiotic Bacterial Fungal	Infection
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .

Cat. No.	Product Name	Type

HY-D1571

CellTracker Blue CMF2HC Dye	Fluorescent Dyes/Probes
CellTracker Blue CMF2HC Dye is a blue dye, can be used in two-channel nuclei acid sequencing, with blue and purple excitation light (450-460 nm/400-405nm or 415-450 nm/480-525nm). CellTracker Blue CMF2HC Dye can be used to rapid determination of antibiotic sensitivity of microorganisms .

Cat. No.	Product Name	Type

HY-B1278B

(±)-α-Tocopherol acetate (±)-Vitamin E acetate	Biochemical Assay Reagents
(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .

Cat. No.	Product Name	Target	Research Area

HY-P3333A

KSPWFTTL TFA	Peptides	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P1934

Cyclo(Phe-Pro) 4 Publications Verification Cyclo(phenylalanylprolyl); A-64863	HCV	Infection
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)), a Vibrio vulnificus quorum-sensing molecule, inhibits retinoic acid-inducible gene-I (RIG-I) polyubiquitination, through its specific interaction with RIG-I, to blunt IRF-3 activation and type-I IFN production. Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) enhances susceptibility to hepatitis C virus (HCV), as well as Sendai and influenza viruses .

HY-P5860

MmTx1 toxin Micrurotoxin 1	GABA Receptor	Neurological Disease
MmTx1 toxin (Micrurotoxin 1) is an allosteric GABA_A receptor modulator that increases GABA_A receptor susceptibility to agonist .

HY-P3333

KSPWFTTL	Peptides	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P5396

GAD65 (524-543)	Peptides	Others
GAD65 (524-543) is a biological active peptide. (This is amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). It is one of the first fragments of this islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. This peptide is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with p524–543 increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0224

Epigoitrin	Alkaloids Classification of Application Fields Cruciferae Source classification Isatis tinctoria L. Plants Disease Research Fields Cancer	Influenza Virus
Epigoitrin is a natural alkaloid from Isatis tinctoria, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling .

HY-N7432

DIMBOA	Infection Structural Classification Zea mays L. Classification of Application Fields Antibiotics Gramineae Source classification Antibacterial Disease Research Plants Disease Research Fields Other Antibiotics	Antibiotic Bacterial Fungal
DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture .

HY-N4117

Hamamelitannin	Infection Hamamelis mollis Oliver Classification of Application Fields Source classification Phenols Polyphenols Hamamelidaceae Plants Disease Research Fields	Bacterial
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release .

HY-N7382

Laburnetin	Laburnum anagyroides Medic. Structural Classification Flavonoids Leguminosae Source classification Plants Isoflavones	Bacterial
Laburnetin is a kind of isoflavone antibacterial agent. Laburnetin has antibacterial activity against fungi and S. vesicarium. Laburnetin intensifies the susceptibility of Methicillin (HY-121544) resistant Staphylococcus aureus (MRSA) strains to Methicillin. Laburnetin can be used to control pests of cultivated species .

Cat. No.	Product Name	Chemical Structure

HY-B0815S

Chlorpyrifos-d10
Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

Cat. No.	Product Name	Application	Reactivity

HY-P80924

TSG101 Antibody TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
TSG101 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to TSG101. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80573

BRCA1 Antibody BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Rat
BRCA1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 208 kDa, targeting to BRCA1. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Rat.

HY-P81169

PD-1 Antibody Programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD-1; hSLE1; PD 1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; Programmed cell death 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Cow, Horse, Rabbit)
PD-1 Antibody is an unconjugated, approximately 32 kDa, rabbit-derived, anti-PD-1 polyclonal antibody. PD-1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: cow, horse, rabbit background without labeling.

HY-P82519

Cellular Apoptosis Susceptibility Antibody (YA2264)

CSE1L; CAS; CSE1; Exp2; Importin-alpha re-exporter; Exportin-2; XPO2
WB, IHC-P, ICC/IF, FC Human, Mouse

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies