Hamamelitannin
Based on 1 Customer Validation
Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release.
For research use only. We do not sell to patients.
- Purity: 99.38%
- CAS No.: 469-32-9
- Formula: C20H20O14
- Molecular Weight:484.36
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 469-32-9
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Appearance Solid
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Molecular Weight 484.36
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Formula C20H20O14
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Color White to off-white
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SMILES
O=C[C@]([C@@H]([C@@H](COC(C1=CC(O)=C(O)C(O)=C1)=O)O)O)(COC(C2=CC(O)=C(O)C(O)=C2)=O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (206.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kiran MD, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol. 2008 May;73(5):1578-86. [Content Brief]
[2]. Cobrado L, et al. In vivo antibiofilm effect of cerium, chitosan and hamamelitannin against usual agents of catheter-related bloodstream infections. J Antimicrob Chemother. 2013 Jan;68(1):126-30. [Content Brief]
[3]. Sánchez-Tena S, et al. Hamamelitannin displays specific cytotoxic activity against colon cancer cells. J Nat Prod. 2012 Jan 27;75(1):26-33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0646 mL | 10.3229 mL | 20.6458 mL | 51.6145 mL |
| 5 mM | 0.4129 mL | 2.0646 mL | 4.1292 mL | 10.3229 mL | |
| 10 mM | 0.2065 mL | 1.0323 mL | 2.0646 mL | 5.1615 mL | |
| 15 mM | 0.1376 mL | 0.6882 mL | 1.3764 mL | 3.4410 mL | |
| 20 mM | 0.1032 mL | 0.5161 mL | 1.0323 mL | 2.5807 mL | |
| 25 mM | 0.0826 mL | 0.4129 mL | 0.8258 mL | 2.0646 mL | |
| 30 mM | 0.0688 mL | 0.3441 mL | 0.6882 mL | 1.7205 mL | |
| 40 mM | 0.0516 mL | 0.2581 mL | 0.5161 mL | 1.2904 mL | |
| 50 mM | 0.0413 mL | 0.2065 mL | 0.4129 mL | 1.0323 mL | |
| 60 mM | 0.0344 mL | 0.1720 mL | 0.3441 mL | 0.8602 mL | |
| 80 mM | 0.0258 mL | 0.1290 mL | 0.2581 mL | 0.6452 mL | |
| 100 mM | 0.0206 mL | 0.1032 mL | 0.2065 mL | 0.5161 mL |
Hamamelitannin Related Classifications
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