469-32-9
469-32-9
Chemical Structure
Hamamelitannin
- CAS No.: 469-32-9
- Formula:C20H20O14
- Molecular Weight:484.36
IUPAC Name: (2R,3R,4R)-2-formyl-2,3,4-trihydroxypentane-1,5-diyl bis(3,4,5-trihydroxybenzoate)
InChIKey: STINYPFJROKCKD-WIBUTAKZSA-N
SMILES: O=C[C@]([C@@H]([C@@H](COC(C1=CC(O)=C(O)C(O)=C1)=O)O)O)(COC(C2=CC(O)=C(O)C(O)=C2)=O)O
Biological Activity: Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Hamamelitannin | 99.38% | Hamamelitannin, a polyphenol extracted from the bark of Hamamelis virginiana, is a quorum-sensing (QS) inhibitor. Hamamelitannin increases antibiotic susceptibility of staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release. | ||||||||||||||||||||
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1,2,6-Tri-O-galloyl-β-D-glucose | 99.0% | 1,2,6-Tri-O-galloyl-β-D-glucose is a polygalloylglucose found in the roots and rhizomes of Sanguisorba officinalis. | ||||||||||||||||||||
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3,5-Di-O-galloylshikimic acid | 3,5-Di-O-galloylshikimic acid is a naturally derived phenolic acid compound with potential antiviral and hepatoprotective activities. 3,5-Di-O-galloylshikimic acid inhibits HIV replication, inactivates HIV viral particles and blocks virus-cell interactions. 3,5-Di-O-galloylshikimic acid has the potential to bind simultaneously to SARS-CoV-2 main protease (Mpro) and human ACE2 receptor. 3,5-Di-O-galloylshikimic acid can be used in studies related to coronavirus disease 2019 (COVID-19), acquired immunodeficiency syndrome (AIDS) and acute liver injury. | |||||||||||||||||||||
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7-O-Galloyl-D-sedoheptulose | 7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications. | |||||||||||||||||||||
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1,7-Di-O-Galloyl-D-sedoheptulose | 1,7-Di-O-Galloyl-D-sedoheptulose is a phenolic acid that can be found in pomegranate arils. | |||||||||||||||||||||
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3,4,6-Tri-O-galloyl-D-glucose | 3,4,6-Tri-O-galloyl-D-glucose (3,4,6-Trigalloylglucose) is an α-amylase (porcine α-amylase IC50 = 334.6 μM; Ki = 307.5 μM) and α-glucosidase (yeast α-glucosidase IC50 = 46.5 μM; Ki = 39.9 μM) mixed type inhibitor. 3,4,6-Tri-O-galloyl-D-glucose exhibits free radical scavenging ability, ferric-reducing power, and antioxidant activity. 3,4,6-Tri-O-galloyl-D-glucose can be used for the research of diabetes. | |||||||||||||||||||||
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3,6-Di-O-galloyl-D-glucopyranoside | 3,6-Di-O-galloyl-D-glucopyranoside is a hydrolyzable tannin compound with astringent activity, found in the leaves of Myrtus communis. | |||||||||||||||||||||
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Gallic acid 3-O-(6′-O-galloyl)-β-D-glucopyranoside | Gallic acid 3-O-(6′-O-galloyl)-β-D-glucopyranoside is a polyphenol that can be found in the fruits of Camellia japonica L.. | |||||||||||||||||||||
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Ginnalin A | Ginnalin A (Acertannin) is a Nrf2 activator. Ginnalin A shows antiproliferative activity against HCT116, SW480 and SW620 cells with IC50 values of 24.8, 22.0, and 39.7 μM, respectively. Ginnalin A can induce cancer cells S phase arrest. Ginnalin A can activate the p62-Keap1-Nrf2 signaling pathway, significantly upregulate the mRNA and protein expression of Nrf2, HO-1, and NQO1, and promote the transport of Nrf2 from the cytoplasm to the nucleus. Ginnalin A can be used for the research of colon cancer. | |||||||||||||||||||||
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2,3,4,6-Tetragalloylglucose | 2,3,4,6-Tetragalloylglucose is a hydrolyzable tannin with antioxidant activity, exhibiting DPPH free radical scavenging activity (IC50=11.35 μM). 2,3,4,6-Tetragalloylglucose can be isolated from the endocarp of Juglans regia (walnut). | |||||||||||||||||||||
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1,6-Di-O-galloyl-β-D-glucose | 91.11% | 1,6-Di-O-galloyl-β-D-glucose is a compound found in the fruit of Phyllanthus emblica. 1,6-Di-O-galloyl-β-D-glucose has HIV-1 reverse transcriptase (RT) inhibitory activity with an IC50 value of 270 μM. 1,6-Di-O-galloyl-β-D-glucose shows competitive inhibition for the template primer and non-competitive inhibition for the substrate (dTTP). 1,6-Di-O-galloyl-β-D-glucose can be used in anti-HIV research. | ||||||||||||||||||||
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References
- [1]. Kiran MD, et al. Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol Pharmacol. 2008 May;73(5):1578-86. [Content Brief]
- [2]. Cobrado L, et al. In vivo antibiofilm effect of cerium, chitosan and hamamelitannin against usual agents of catheter-related bloodstream infections. J Antimicrob Chemother. 2013 Jan;68(1):126-30. [Content Brief]
