1,6-Di-O-galloyl-β-D-glucose
Based on 1 Customer Validation
1,6-Di-O-galloyl-β-D-glucose is a compound found in the fruit of Phyllanthus emblica. 1,6-Di-O-galloyl-β-D-glucose has HIV-1 reverse transcriptase (RT) inhibitory activity with an IC50 value of 270 μM. 1,6-Di-O-galloyl-β-D-glucose shows competitive inhibition for the template primer and non-competitive inhibition for the substrate (dTTP). 1,6-Di-O-galloyl-β-D-glucose can be used in anti-HIV research.
For research use only. We do not sell to patients.
- Purity: 91.11%
- CAS No.: 23363-08-8
- Formula: C20H20O14
- Molecular Weight:484.36
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
>10 μg/mL
Compound: 5
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Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
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[PMID: 1431932] |
| HCT-8 | ED50 |
>10 μg/mL
Compound: 5
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Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
|
[PMID: 1431932] |
| KB | ED50 |
>10 μg/mL
Compound: 5
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Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
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[PMID: 1431932] |
| TE-671 | ED50 |
>10 μg/mL
Compound: 5
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Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
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[PMID: 1431932] |
In Vitro
1,6-Di-O-galloyl-β-D-glucose (Compound 2) weakly inhibits purified HIV-1 reverse transcriptase with an IC50 of 270 μM, acting via a non-competitive mode with respect to dTTP (Ki = 160 μM) and a competitive mode with respect to the template-primer (rA)n-p(dT)12-18 (Ki = 96.0 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 23363-08-8
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Appearance Solid
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Molecular Weight 484.36
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Formula C20H20O14
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Color Brown to black
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SMILES
O=C(C1=CC(O)=C(C(O)=C1)O)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)COC(C3=CC(O)=C(C(O)=C3)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,6-Di-O-galloyl-β-D-glucose Related Classifications
HY-W719041 Related Classifications
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