2. NF-κB Autophagy Metabolic Enzyme/Protease
  3. Keap1-Nrf2 p62 Heme Oxygenase (HO)
  4. Ginnalin A

Ginnalin A (Acertannin) is a Nrf2 activator. Ginnalin A shows antiproliferative activity against HCT116, SW480 and SW620 cells with IC50 values of 24.8, 22.0, and 39.7 μM, respectively. Ginnalin A can induce cancer cells S phase arrest. Ginnalin A can activate the p62-Keap1-Nrf2 signaling pathway, significantly upregulate the mRNA and protein expression of Nrf2, HO-1, and NQO1, and promote the transport of Nrf2 from the cytoplasm to the nucleus. Ginnalin A can be used for the research of colon cancer.

For research use only. We do not sell to patients.

Ginnalin A

Ginnalin A Chemical Structure

CAS No. : 76746-56-0

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Ginnalin A Related Antibodies

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HO-1 HO-2

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Description

Ginnalin A (Acertannin) is a Nrf2 activator. Ginnalin A shows antiproliferative activity against HCT116, SW480 and SW620 cells with IC50 values of 24.8, 22.0, and 39.7 μM, respectively. Ginnalin A can induce cancer cells S phase arrest. Ginnalin A can activate the p62-Keap1-Nrf2 signaling pathway, significantly upregulate the mRNA and protein expression of Nrf2, HO-1, and NQO1, and promote the transport of Nrf2 from the cytoplasm to the nucleus. Ginnalin A can be used for the research of colon cancer[1].

IC50 & Target[1]

HO-1

 

Molecular Weight

468.37

Formula

C20H20O13
CAS No.
SMILES

O(C(=O)C1=CC(O)=C(O)C(O)=C1)[C@@H]2[C@@H](O)[C@H](O)[C@@H](COC(=O)C3=CC(O)=C(O)C(O)=C3)OC2
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ginnalin A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ginnalin A76746-56-0AcertanninKeap1-Nrf2p62Heme Oxygenase (HO)Sequestosome-1SQSTM1Heme OxygenaseInhibitorinhibitorinhibit

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