2. Anti-infection Metabolic Enzyme/Protease
  3. HIV Protease
  4. TMC310911

TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity.

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TMC310911 Chemical Structure

TMC310911 Chemical Structure

CAS No. : 1000287-05-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 275 In-stock
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid
1 mg USD 85 In-stock
5 mg USD 250 In-stock
10 mg USD 440 In-stock
25 mg USD 930 In-stock
50 mg USD 1650 In-stock
100 mg USD 3000 In-stock
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Based on 1 publication(s) in Google Scholar

TMC310911 Related Antibodies

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Description

TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity[1][2].

IC50 & Target

EC50: 2.2-14.2 nM (Wild-type HIV-1)[1]
In Vitro

For a panel of 2,011 recombinant isolates with decreased susceptibility to at least one of the currently approved protease inhibitors (PIs), the FC in TMC310911 EC50 is ≤4 for 82% of isolates and ≤10 for 96% of isolates. The fold change (FC) in TMC310911 EC50 is ≤4 and ≤10 for 72% and 94% of isolates with decreased susceptibility to Darunavir, respectively. In vitro resistance selection (IVRS) performed with r13025, a multiple-PI-resistant recombinant isolate, and TMC310911 selected for mutations L10F, I47V, and L90M (FC in TMC310911 EC50 = 16)[1].
The TMC310911 EC50 values against HIV-1/LAI and HIV-2/ROD in MT4 cells with EC50 values of 14.2 nM and 2 nM, respectively, and HIV-1/LAI and HIV-1/SF2 in PBMCs with EC50 values of 2.2 nM and 2.3 nM, respectively, and HIV-1/BaL in M/M cells with an EC50 value of 13.9 nM. And the corresponding EC90 values ranged from 5.0 to 94.7 nM. The TMC310911 CC50 for MT4 cells is 9.9 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TMC310911 Related Antibodies
Clinical Trial
Molecular Weight

755.99

Formula

C38H53N5O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@@H]1[C@@]2([H])[C@@](OCC2)([H])OC1)N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C5N=C(NC6CCN(C7CCCC7)CC6)SC5=C4)=O)CC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (132.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3228 mL 6.6138 mL 13.2277 mL
5 mM 0.2646 mL 1.3228 mL 2.6455 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3228 mL 6.6138 mL 13.2277 mL 33.0692 mL
5 mM 0.2646 mL 1.3228 mL 2.6455 mL 6.6138 mL
10 mM 0.1323 mL 0.6614 mL 1.3228 mL 3.3069 mL
15 mM 0.0882 mL 0.4409 mL 0.8818 mL 2.2046 mL
20 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.6535 mL
25 mM 0.0529 mL 0.2646 mL 0.5291 mL 1.3228 mL
30 mM 0.0441 mL 0.2205 mL 0.4409 mL 1.1023 mL
40 mM 0.0331 mL 0.1653 mL 0.3307 mL 0.8267 mL
50 mM 0.0265 mL 0.1323 mL 0.2646 mL 0.6614 mL
60 mM 0.0220 mL 0.1102 mL 0.2205 mL 0.5512 mL
80 mM 0.0165 mL 0.0827 mL 0.1653 mL 0.4134 mL
100 mM 0.0132 mL 0.0661 mL 0.1323 mL 0.3307 mL
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TMC310911 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMC3109111000287-05-7ASC-09TMC 310911TMC-310911ASC09ASC 09HIV ProteaseDarunavirHIV-1antiviralrecombinantmultiple-PI-resistantbroadsusceptibilitygeneticbarrierInhibitorinhibitorinhibit

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