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trans-isomer

" in MedChemExpress (MCE) Product Catalog:

標的別:	Acyltransferase (1) AMPK (2) Apoptosis (1) Autophagy (1) Bcr-Abl (1) Btk (1) COX (1) Drug Isomer (5) Endogenous Metabolite (3) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (1) Fungal (1) Glucokinase (2) HCV (1) Isotope-Labeled Compounds (1) mAChR (1) Opioid Receptor (1) P2Y Receptor (1) PERK (1) PGE synthase (1) PPAR (4) Prostaglandin Receptor (2) PROTACs (1) Reference Standards (1) Sodium Channel (1) TRP Channel (1)
研究分野別:	Cancer (3) Cardiovascular Disease (4) Endocrinology (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (11) Neurological Disease (3)

標的別:

Acyltransferase (1)

AMPK (2)

Apoptosis (1)

Autophagy (1)

Bcr-Abl (1)

Btk (1)

COX (1)

Drug Isomer (5)

Endogenous Metabolite (3)

Epigenetic Reader Domain (1)

Eukaryotic Initiation Factor (eIF) (1)

Fungal (1)

Glucokinase (2)

HCV (1)

Isotope-Labeled Compounds (1)

mAChR (1)

Opioid Receptor (1)

P2Y Receptor (1)

PERK (1)

PGE synthase (1)

PPAR (4)

Prostaglandin Receptor (2)

PROTACs (1)

Reference Standards (1)

Sodium Channel (1)

TRP Channel (1)

研究分野別:

Cancer (3)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (3)

Metabolic Disease (11)

Neurological Disease (3)

阻害剤およびアゴニスト

天然物

同位体標識化合物

製品番号	製品名	Target	研究分野	構造式

HY-12495

*ISRIB (trans-isomer)* Maximum Cited Publications 46 Publications Verification	PERK Autophagy Apoptosis	Neurological Disease
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC₅₀ of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC₅₀=5 nM).

HY-N2341

Palmitelaidic acid 3 Publications Verification 9-trans-Hexadecenoic acid; trans-Palmitoleic acid	AMPK PPAR Glucokinase	Metabolic Disease
Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

HY-125021

2BAct 3 Publications Verification	Eukaryotic Initiation Factor (eIF)	Neurological Disease
2BAct is a highly selective, orally active, and CNS-penetrant eIF2B (eukaryotic initiation factor 2B) activator with an EC₅₀ of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) .

HY-N1867

trans-Cinnamyl alcohol	PPAR	Metabolic Disease
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .

HY-134819

(1S,2S)-ML-SI3 (+)-trans-ML-SI3	TRP Channel	Cancer
(1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC₅₀=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC₅₀=5.9 μM) .

HY-151232

(E/Z)-Rilzabrutinib (E/Z)-PRN1008	Btk	Inflammation/Immunology
(E/Z)-Rilzabrutinib ((E/Z)-PRN1008) is a cis-trans isomer of Rilzabrutinib (HY-112166). Rilzabrutinib is a BTK inhibitor .

HY-123669A

trans-R-138727	P2Y Receptor	Cardiovascular Disease
Trans-R-138727 is the trans isomer of R-138727 (HY-123669). R-138727 is the active metabolite of the antiplatelet agent Prasugrel (HY-15284). R-138727 is an irreversible inhibitor for the platelet receptor P2Y12, and inhibits ADP-induced platelet activation and aggregation .

HY-W073501

trans-Glutaconic acid trans-2-Pentenedioic acid	Drug Isomer Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
trans-Glutaconic acid (trans-2-Pentenedioic acid) is the trans isomer of Glutaconic acid (HY-W073501A). trans-Glutaconic acid is a neurotoxic metabolite. trans-Glutaconic acid induces weak neurotoxicity in cultured cerebral neocortical neurons. trans-Glutaconic acid elicits significant electrophysiological responses in rat neocortical wedge preparations at high concentrations. trans-Glutaconic acid can be used in studies related to glutaric acidemia type 1 .

HY-124141

Myristelaidic acid trans-9-Tetradecenoic acid	Endogenous Metabolite	Metabolic Disease
Myristelaidic acid (trans-9-Tetradecenoic acid), a 14-carbon trans fatty acid, is the trans isomer of Myristoleic acid. Myristelaidic acid is found in most animal fats .

HY-135163

trans-Latanoprost (5E)-Latanoprost; 5,6-trans-Latanoprost	Prostaglandin Receptor	Others
trans-Latanoprost (5,6-trans-Latanoprost) is the trans isomer of Latanoprost (HY-B0577). trans-Latanoprost is promising for research of glaucoma and high eye pressure .

HY-119254A

trans-BAY-850	Epigenetic Reader Domain	Metabolic Disease
trans-BAY-850 is the trans isomer of BAY-850 (HY-119254). BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC₅₀ of 166 nM.

HY-116459

trans-Cevimeline hydrochloride AF102A hydrochloride	mAChR	Neurological Disease
Trans-Cevimeline (AF102A) (hydrochloride), as a trans-isomer of AF102B, is a M1 selective cholinergic agonist. Trans-Cevimeline (AF102A) (hydrochloride) can be used for the research of Alzheimer's disease .

HY-W342979

Petroselaidic acid trans-Petroselinic acid; trans-6-Octadecenoic acid	Drug Isomer	Others
Petroselaidic acid is a trans fatty acid and the trans isomer of Petroselinic acid (HY-113362). Petroselaidic acid can be found in dairy products such as cow's milk and goat's milk .

HY-N2341S

Palmitelaidic acid-d13	AMPK PPAR Glucokinase	Metabolic Disease
Palmitelaidic acid-d₁₃ is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

HY-W700726

*cis-Atovaquone-d5 (contains 10% trans isomer)*	Isotope-Labeled Compounds	Others
cis-Atovaquone-d₅ (contains 10% trans isomer) is the deuterium labeled cis-Atovaquone.

HY-N1867R

trans-Cinnamyl alcohol (Standard)	Reference Standards PPAR	Metabolic Disease
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .

HY-176106

1-Naphthyl U-47700	Opioid Receptor	Others
1-Naphthyl U-47700 is an α-isomer. 1-Naphthyl U-47700 is a racemic mixtures of the trans-isomers [R,R and S,S]. 1-Naphthyl U-47700 activates MOR in a concentration-dependent manner (EC₅₀ > 23 μM) .

HY-166088

Myristelaidic acid sodium trans-9-Tetradecenoic acid sodium	Endogenous Metabolite	Metabolic Disease
Myristelaidic acid (trans-9-Tetradecenoic acid) sodium, a 14-carbon trans fatty acid, is the trans isomer of Myristoleic acid. Myristelaidic acid is found in most animal fats .

HY-122178

*5-trans* U-44069**	PGE synthase	Cardiovascular Disease
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits prostaglandin E2 synthase activity .

HY-148384B

trans-UHMCP1	Drug Isomer	Cancer
Trans-UHMCP1 is the trans-isomer of UHMCP1 (HY-148384). UHMCP1 is a chemical probe of the U2AF homologous motif (UHM), with a K_d value of 79 μM. UHMCP1 inhibits the interaction between SF3b155/U2AF ⁶⁵, affecting RNA splicing and cell viability. UHMCP1 has potential anti-cancer properties .

HY-N16849

Myristinin A YM 26567-1	COX Prostaglandin Receptor Fungal	Infection Inflammation/Immunology
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC₅₀ of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC₅₀ of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis .

HY-N18387

trans-Psoralenoside	Drug Isomer	Metabolic Disease Inflammation/Immunology Endocrinology
trans-Psoralenoside is the trans isomer of Psoralenoside (HY-N7503). trans-Psoralenoside is present in the aerial parts of Ficus palmata. trans-Psoralenoside can be used in studies of liver diseases, kidney diseases and peptic ulcers .

HY-158782

*5-trans* Bimatoprost acid**	Others	Metabolic Disease
5-trans-17-phenyl trinor Prostaglandin F2α (5-trans-17-phenyl trinor PGF2α) is the 5-trans isomer of HY-B0191 Bimatoprost (17-phenyl trinor PGF2α).

HY-182334

azo-Q2a	Sodium Channel	Cardiovascular Disease
azo-Q2a is a photoswitchable Na_V1.5 inhibitor. azo-Q2a exists as the trans isomer with low activity in the dark or under 480 nm illumination, and exists as the cis isomer with higher inhibitory potency under 365 nm illumination. azo-Q2a reduces the heart rate of living zebrafish larvae in a light-dependent manner. azo-Q2a can be used for the study of arrhythmias .

HY-107176

(E)-Hyzetimibe (E)-HS-25	Drug Isomer HCV Acyltransferase	Infection Metabolic Disease
(E)-Hyzetimibe ((E)-HS-25) (Compound I-1Z) is the trans isomer of Hyzetimibe (HY-107176A), a cholesterol-lowering agent. (E)-Hyzetimibe has cholesterol acyltransferase (ACTA) inhibitory activity, but its cholesterol-lowering effect is relatively weak. (E)-Hyzetimibe can inhibit the entry of hepatitis C virus (HCV) into host cells, and it has a synergistic effect when used in combination with interferon-α. (E)-Hyzetimibe can be used for the study of HCV infection .

HY-180985

Azo-PROTAC-4C-cis	PROTACs Bcr-Abl	Cancer
Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia .

製品番号	製品名	Category	Target	構造式

HY-N2341

Palmitelaidic acid 3 Publications Verification 9-trans-Hexadecenoic acid; trans-Palmitoleic acid	Animals Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Disease Research Fields Source Classification	AMPK PPAR Glucokinase
Palmitelaidic acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

HY-N1867

trans-Cinnamyl alcohol	天然物 Rosaceae Plants Source Classification	PPAR
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .

HY-124141

Myristelaidic acid trans-9-Tetradecenoic acid	Classification of Application Fields Animals Ketones, Aldehydes, Acids Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite
Myristelaidic acid (trans-9-Tetradecenoic acid), a 14-carbon trans fatty acid, is the trans isomer of Myristoleic acid. Myristelaidic acid is found in most animal fats .

HY-N1867R

trans-Cinnamyl alcohol (Standard)	Structural Classification 天然物 Rosaceae Plants Source Classification	Reference Standards PPAR
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .

HY-N16849

Myristinin A YM 26567-1	Structural Classification Horsfieldia amygdalina (Wall. ex Hook. f. & Thomson) Warb. Coumarins Myristicaceae Phenylpropanoids Plants Source Classification	COX Prostaglandin Receptor Fungal
Myristinin A (YM 26567-1) is a trans-isomer flavan compound found in Horsfieldia amygdaline and Myristica cinnamomea. Myristinin A can selectively inhibit COX-2 activity with an IC₅₀ of 16.9 μg/mL. Myristinin A can reduce the production of prostaglandin E2 (PGE2) and inhibit phospholipase A2 (PLA2), thereby blocking the release of inflammatory mediators. Myristinin A can inhibit Candida albicans with an IC₅₀ of 8.8 μg/mL. Myristinin A can be used for the research of inflammation and infection, such as rheumatoid arthritis .

HY-N18387

trans-Psoralenoside	Structural Classification Ketones, Aldehydes, Acids Ficus palmata Forssk. Plants Moraceae Source Classification	Drug Isomer
trans-Psoralenoside is the trans isomer of Psoralenoside (HY-N7503). trans-Psoralenoside is present in the aerial parts of Ficus palmata. trans-Psoralenoside can be used in studies of liver diseases, kidney diseases and peptic ulcers .

製品番号	製品名	構造式

HY-N2341S

Palmitelaidic acid-d13
Palmitelaidic acid-d₁₃ is the deuterium labeled Palmitelaidic Acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.

HY-W700726

*cis-Atovaquone-d5 (contains 10% trans isomer)*
cis-Atovaquone-d₅ (contains 10% trans isomer) is the deuterium labeled cis-Atovaquone.

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