(E/Z)-Rilzabrutinib
Based on 1 publication(s) in Google Scholar
(E/Z)-Rilzabrutinib ((E/Z)-PRN1008) is a cis-trans isomer of Rilzabrutinib (HY-112166). Rilzabrutinib is a BTK inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 1575591-66-0
- Formula: C36H40FN9O3
- Molecular Weight:665.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) (E/Z)-Rilzabrutinib
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| B cell | IC50 |
123 nM
Compound: 12; PRN1008
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Inhibition of anti-IgM-stimulated CD20+ B cell activation in human whole blood assessed as measuring CD69 expression level pretreated for 1 hr followed by anti-IgM stimulation measured after 18 hrs by flow cytometry
Inhibition of anti-IgM-stimulated CD20+ B cell activation in human whole blood assessed as measuring CD69 expression level pretreated for 1 hr followed by anti-IgM stimulation measured after 18 hrs by flow cytometry
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[PMID: 35302767] |
Rilzabrutinib (PRN1008) is an orally active BTK inhibitor with anti-inflammatory and immunomodulatory activities. Rilzabrutinib can be used in the research of various inflammatory and immune-related diseases such as acute respiratory distress syndrome and sepsis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1575591-66-0
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Molecular Weight 665.76
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Formula C36H40FN9O3
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SMILES
NC1=C2C(C3=C(C=C(OC4=CC=CC=C4)C=C3)F)=NN([C@H]5CN(CCC5)C(/C(C#N)=C/C(C)(N6CCN(C7COC7)CC6)C)=O)C2=NC=N1
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Synonyms
(E/Z)-PRN1008
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)