1. Cell Cycle/DNA Damage
  2. Eukaryotic Initiation Factor (eIF)
  3. 2BAct

2BAct 

Cat. No.: HY-125021 Purity: 98.70%
Handling Instructions

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB (HY-12495).

For research use only. We do not sell to patients.

2BAct Chemical Structure

2BAct Chemical Structure

CAS No. : 2143542-28-1

Size Price Stock Quantity
5 mg USD 660 In-stock
Estimated Time of Arrival: December 31
10 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB (HY-12495)[1].

IC50 & Target

EC50: 33 nM (eIF2B)[1]

In Vitro

Primary fibroblast lysates from R191H embryos has lower GEF activity than WT lysates, and 2BAct enhances this activity threefold (EC50=7.3 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

2BAct (300 µg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice[1].
2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice[1].
2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

440.80

Formula

C₁₉H₁₆ClF₃N₄O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (567.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2686 mL 11.3430 mL 22.6860 mL
5 mM 0.4537 mL 2.2686 mL 4.5372 mL
10 mM 0.2269 mL 1.1343 mL 2.2686 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
2BAct
Cat. No.:
HY-125021
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