2143542-28-1
Chemical Structure
2BAct
- CAS No.: 2143542-28-1
- Formula:C19H16ClF3N4O3
- Molecular Weight:440.80
IUPAC Name: N-(3-(2-(4-chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide
InChIKey: HYQJXXCYOYRNMP-UHFFFAOYSA-N
SMILES: O=C(C(C=N1)=NC=C1C(F)F)NC(C2)(C3)CC23NC(COC(C=C4)=CC(F)=C4Cl)=O
Biological Activity: 2BAct is a highly selective, orally active, and CNS-penetrant eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2BAct | 99.77% | 2BAct is a highly selective, orally active, and CNS-penetrant eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495). | ||||||||||||||||||||
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Keywords
