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Cat. No.: HY-W073501

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trans-Glutaconic acid

(Synonyms: trans-2-Pentenedioic acid)

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trans-Glutaconic acid (trans-2-Pentenedioic acid) is the trans isomer of Glutaconic acid (HY-W073501A). trans-Glutaconic acid is a neurotoxic metabolite. trans-Glutaconic acid induces weak neurotoxicity in cultured cerebral neocortical neurons. trans-Glutaconic acid elicits significant electrophysiological responses in rat neocortical wedge preparations at high concentrations. trans-Glutaconic acid can be used in studies related to glutaric acidemia type 1.

For research use only. We do not sell to patients.

Purity: 98.92%
CAS No.: 628-48-8
Formula: C₅H₆O₄
Molecular Weight:130.10

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

trans-Glutaconic acid Chemical Structure

CAS No.: 628-48-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

IC₅₀ & Target^[1]

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

trans-Glutaconic acid (1-10 mM; 24 h) weakly reduces viability of primary murine cerebral neocortical neurons, causing a 14% reduction at 1 mM and a 23-29% reduction at 10 mM after 24 h, with partial protection against toxicity provided by 100 μM APV^[1].
trans-Glutaconic acid (10 mM) does not activate or synergize with glutamate to activate NR1/NR2A or NR1/NR2B NMDA receptor subunits expressed in Xenopus oocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 628-48-8
Appearance Solid
Molecular Weight 130.10
Formula C₅H₆O₄
Color White to off-white
SMILES

O=C(O)/C=C/CC(O)=O
Synonyms

trans-2-Pentenedioic acid
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lund TM, et al. On the neurotoxicity of glutaric, 3-hydroxyglutaric, and trans-glutaconic acids in glutaric acidemia type 1. J Neurosci Res. 2004;77(1):143-147. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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trans-Glutaconic acid

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trans-Glutaconic acid

Metabolism/Protease Compound Library

Human Endogenous Metabolite Compound Library

Anti-Cardiovascular Disease Compound Library

Animal-Sourced Natural Product Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Endogenous Metabolite Library

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

trans-Glutaconic acid Related Classifications

HY-W073501 Related Classifications