2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Adrenergic Receptor Endogenous Metabolite
  4. Synephrine hydrochloride

Synephrine hydrochloride  (Synonyms: Oxedrine hydrochloride)

Cat. No.: HY-N0132A Purity: 99.66%
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Handling Instructions Technical Support

Synephrine (Oxedrine) hydrochloride, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss.

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Synephrine hydrochloride

Synephrine hydrochloride 화학구조

CAS No. : 5985-28-4

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 g 해외재고보유
5 g 해외재고보유
10 g 해외재고보유
50 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of Synephrine hydrochloride:

Synephrine hydrochloride Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Synephrine hydrochloride

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms
α adrenergic receptor β adrenergic receptor

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Human Endogenous Metabolite Microbial Metabolite

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Synephrine (Oxedrine) hydrochloride, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss[1][2].

IC50 & Target

β adrenergic receptor

 

In Vivo

Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Portal vein ligation (PVL) or bile duct ligation (BDL) rats[2]
Dosage: 1 mg/kg per 12 hours
Administration: Oral gavage; for 8 days
Result: The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.
분자량

203.67

화학식

C9H14ClNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=C(O)C=C1)CNC.Cl
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

H2O : ≥ 100 mg/mL (490.99 mM)

DMSO : ≥ 52 mg/mL (255.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9099 mL 24.5495 mL 49.0990 mL
5 mM 0.9820 mL 4.9099 mL 9.8198 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.9099 mL 24.5495 mL 49.0990 mL 122.7476 mL
5 mM 0.9820 mL 4.9099 mL 9.8198 mL 24.5495 mL
10 mM 0.4910 mL 2.4550 mL 4.9099 mL 12.2748 mL
15 mM 0.3273 mL 1.6366 mL 3.2733 mL 8.1832 mL
20 mM 0.2455 mL 1.2275 mL 2.4550 mL 6.1374 mL
25 mM 0.1964 mL 0.9820 mL 1.9640 mL 4.9099 mL
30 mM 0.1637 mL 0.8183 mL 1.6366 mL 4.0916 mL
40 mM 0.1227 mL 0.6137 mL 1.2275 mL 3.0687 mL
50 mM 0.0982 mL 0.4910 mL 0.9820 mL 2.4550 mL
60 mM 0.0818 mL 0.4092 mL 0.8183 mL 2.0458 mL
80 mM 0.0614 mL 0.3069 mL 0.6137 mL 1.5343 mL
100 mM 0.0491 mL 0.2455 mL 0.4910 mL 1.2275 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Synephrine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Synephrine5985-28-4OxedrineAdrenergic ReceptorEndogenous MetaboliteBeta Receptorα-adrenergicβ-adrenergicsympathomimeticalkaloidweightlossInhibitorinhibitorinhibit

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상품명:
Synephrine hydrochloride
Cat. No.:
HY-N0132A
수량:
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