1. Neuronal Signaling
    GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Adrenergic Receptor
    Endogenous Metabolite
  3. Synephrine

Synephrine (Synonyms: Oxedrine)

Cat. No.: HY-N0132
Handling Instructions

Synephrine (Oxedrine) is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids.

For research use only. We do not sell to patients.

Synephrine Chemical Structure

Synephrine Chemical Structure

CAS No. : 94-07-5

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Description

Synephrine (Oxedrine) is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids[1][2].

IC50 & Target

α-adrenergic and β-adrenergic[1]

In Vivo

Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine[2].

Animal Model: Portal vein ligation (PVL) or bile duct ligation (BDL) rats[2]
Dosage: 1 mg/kg per 12 hours
Administration: Oral gavage; for 8 days
Result: The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.
Molecular Weight

167.21

Formula

C₉H₁₃NO₂

CAS No.

94-07-5

SMILES

OC(C1=CC=C(O)C=C1)CNC

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SynephrineOxedrineAdrenergic ReceptorEndogenous MetaboliteBeta ReceptorInhibitorinhibitorinhibit

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Synephrine
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