2. Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Dopamine Receptor Adrenergic Receptor mAChR Sigma Receptor Histamine Receptor
  4. Thiothixene

Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

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Thiothixene

Thiothixene Chemische Struktur

CAS. Nr. : 5591-45-7

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Other Forms of Thiothixene:

Thiothixene Related Antibodies

Top Publications Citing Use of Products

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
α adrenergic receptor β adrenergic receptor

Alle mAChR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Alle Sigma Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Sigma 1 Receptor Sigma 2 Receptor

Alle Histamine Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Beschreibung

Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

Klinische Studie
Molekulargewicht

443.63

Formel

C23H29N3O2S2
CAS. Nr.
SMILES

O=S(C1=CC(/C2=C/CCN3CCN(C)CC3)=C(SC4=C2C=CC=C4)C=C1)(N(C)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
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Thiothixene Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiothixene5591-45-7NSC 108165 Navan NavaneNSC108165NSC-108165Dopamine ReceptorAdrenergic ReceptormAChRSigma ReceptorHistamine ReceptorBeta ReceptorMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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