2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. Cytochrome P450 ROS Kinase
  4. Uniconazole

Uniconazole 

Cat. No.: HY-B0873 Purity: 99.68%
COA Handling Instructions

Uniconazole, a plant growth retardant, is a potent inhibitor of abscisic acid (ABA) catabolism with an IC50 of 68 nM against ABA 8’-hydroxylase. Uniconazole is a potent competitive inhibitor of CYP707A3 activity with a Ki of 8 nM. Uniconazole evidently inhibits gibberellin biosynthesis, and brassinosteroid biosynthesis is also inhibited to some extent.

For research use only. We do not sell to patients.

Uniconazole Chemical Structure

Uniconazole Chemical Structure

CAS No. : 83657-22-1

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Based on 1 publication(s) in Google Scholar

Uniconazole Related Antibodies

Top Publications Citing Use of Products

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 CYP19 CYP26 CYP51

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Description

Uniconazole, a plant growth retardant, is a potent inhibitor of abscisic acid (ABA) catabolism with an IC50 of 68 nM against ABA 8’-hydroxylase. Uniconazole is a potent competitive inhibitor of CYP707A3 activity with a Ki of 8 nM. Uniconazole evidently inhibits gibberellin biosynthesis, and brassinosteroid biosynthesis is also inhibited to some extent[1].

IC50 & Target

IC50: 68 nM (ABA 8’-hydroxylase)[1]
Ki: 8 nM (CYP707A3 activity)[1]
In Vivo

Uniconazole (0-50 μM) effectively blocks ABA 8’-hydroxylase activity and enhances drought tolerance in vivo[1].
Uniconazole increases the activities of antioxidant enzymes, promotes accumulation of proline and soluble sugars, and reduces accumulation of malondialdehyde[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Arabidopsis[1]
Dosage: 0.5, 1, 5, 25, 50 μM
Administration:
Result: Inhibited PA (phaseic acid) production and enhanced drought tolerance.
Molecular Weight

291.78

Appearance

Solid

Formula

C15H18ClN3O
CAS No.
SMILES

OC(C(C)(C)C)/C(N1N=CN=C1)=C\C2=CC=C(Cl)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.72 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4272 mL 17.1362 mL 34.2724 mL
5 mM 0.6854 mL 3.4272 mL 6.8545 mL
10 mM 0.3427 mL 1.7136 mL 3.4272 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.57 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.68%

COA (252 KB) HNMR (265 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References
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Uniconazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Uniconazole83657-22-1Cytochrome P450ROS KinaseCYPsgibberellinbrassinosteroidCYP707A3P450abscisic acidInhibitorinhibitorinhibit

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