2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CCR HIV
  4. Vicriviroc

Vicriviroc  (Synonyms: SCH 417690; SCH-D; MK-7690 free base)

製品番号: HY-B0155
取扱説明書 Technical Support

Vicriviroc (SCH 417690) is an orally active CCR5 antagonist with the IC50 of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC50 values of 0.91 nM and 16 nM,,respectively. Vicriviroc can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer.

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Vicriviroc

Vicriviroc 構造式

CAS 番号 : 306296-47-9

容量 在庫状況
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Other 在庫あり Forms of Vicriviroc:

Other Forms of Vicriviroc:

Vicriviroc 関連抗体

Top Publications Citing Use of Products

CCR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

HIV アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HIV HIV-1 HIV-2

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製品説明

Vicriviroc (SCH 417690) is an orally active CCR5 antagonist with the IC50 of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC50 values of 0.91 nM and 16 nM,,respectively. Vicriviroc can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer[1][2].

Cellular Effect
Cell Line Type Value Description References
MT4 CC50
> 5 μM
Compound: SCH-D
Cytotoxicity against human MT4 cells by MTT assay
Cytotoxicity against human MT4 cells by MTT assay
[PMID: 26094944]
MT4 CC50
> 5 μM
Compound: SCH-D
Cytotoxicity against human MT4 cells by MTT assay in presence of 5 uM of chloroquine
Cytotoxicity against human MT4 cells by MTT assay in presence of 5 uM of chloroquine
[PMID: 26094944]
MT4 CC50
> 5 μM
Compound: SCH-D; Sch-417690
Cytotoxicity against Human immunodeficiency virus 1 NL4-3 infected in human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
Cytotoxicity against Human immunodeficiency virus 1 NL4-3 infected in human MT4 cells assessed as reduction in cell viability measured after 5 days by MTT assay
[PMID: 32305183]
MT4 CC50
> 5 μM
Compound: SCH-D; Sch-417690
Cytotoxicity against in human MT-4 after 5 days by MTT assay
Cytotoxicity against in human MT-4 after 5 days by MTT assay
[PMID: 33316719]
MT4 EC50
> 5 μM
Compound: SCH-D
Antiviral activity against T-cell line-tropic HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 5 days by MTT assay
Antiviral activity against T-cell line-tropic HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 5 days by MTT assay
[PMID: 26094944]
MT4 EC50
> 5 μM
Compound: SCH-D
Antiviral activity against T-cell line-tropic HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 5 days by MTT assay in presence of 5 uM of chloroquine
Antiviral activity against T-cell line-tropic HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 5 days by MTT assay in presence of 5 uM of chloroquine
[PMID: 26094944]
PBMC IC50
0.23 nM
Compound: Sch-D
Antiviral activity against HIV-1 BaL infected in PHA-stimulated human PBMC cells assessed as viral p24 core protein level after 7 days by ELISA
Antiviral activity against HIV-1 BaL infected in PHA-stimulated human PBMC cells assessed as viral p24 core protein level after 7 days by ELISA
[PMID: 24900235]
PBMC IC50
0.56 nM
Compound: Sch-D
Antiviral activity against HIV-1 ADA infected in PHA-stimulated human PBMC cells assessed as viral p24 core protein level after 7 days by ELISA
Antiviral activity against HIV-1 ADA infected in PHA-stimulated human PBMC cells assessed as viral p24 core protein level after 7 days by ELISA
[PMID: 24900235]
PBMC IC50
1.2 nM
Compound: Sch-D
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis
[PMID: 24900235]
分子量

533.63

分子式

C28H38F3N5O2
CAS 番号
SMILES

COC[C@@H](C1=CC=C(C=C1)C(F)(F)F)N2[C@H](CN(C3(CCN(CC3)C(C4=C(C)N=CN=C4C)=O)C)CC2)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Vicriviroc Related Classifications

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質量   濃度   体積   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vicriviroc306296-47-9SCH 417690 SCH-DMK-7690SCH417690SCH-417690MK7690MK 7690CCRHIVCC chemokine receptorHuman immunodeficiency virusBa/F3-CCR5 cellsColorectal CancerHIV-1Inhibitorinhibitorinhibit

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製品名:
Vicriviroc
製品番号:
HY-B0155
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