2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. XAP044

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.

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XAP044

XAP044 Chemische Struktur

CAS. Nr. : 196928-50-4

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XAP044 Related Antibodies

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Alle mGluR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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Beschreibung

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].

Molekulargewicht

380.13

Formel

C15H9IO4
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=C(O)C=C2OC=C1OC3=CC=C(I)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : ≥ 50 mg/mL (131.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6307 mL 13.1534 mL 26.3068 mL
5 mM 0.5261 mL 2.6307 mL 5.2614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6307 mL 13.1534 mL 26.3068 mL 65.7670 mL
5 mM 0.5261 mL 2.6307 mL 5.2614 mL 13.1534 mL
10 mM 0.2631 mL 1.3153 mL 2.6307 mL 6.5767 mL
15 mM 0.1754 mL 0.8769 mL 1.7538 mL 4.3845 mL
20 mM 0.1315 mL 0.6577 mL 1.3153 mL 3.2883 mL
25 mM 0.1052 mL 0.5261 mL 1.0523 mL 2.6307 mL
30 mM 0.0877 mL 0.4384 mL 0.8769 mL 2.1922 mL
40 mM 0.0658 mL 0.3288 mL 0.6577 mL 1.6442 mL
50 mM 0.0526 mL 0.2631 mL 0.5261 mL 1.3153 mL
60 mM 0.0438 mL 0.2192 mL 0.4384 mL 1.0961 mL
80 mM 0.0329 mL 0.1644 mL 0.3288 mL 0.8221 mL
100 mM 0.0263 mL 0.1315 mL 0.2631 mL 0.6577 mL
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XAP044 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XAP044196928-50-4XAP 044XAP-044mGluRMetabotropic glutamate receptorsmGlu7neurotransmissionCNSbrain exposurewide spectrumanti-stressantidepressantanxiolytic-likeInhibitorinhibitorinhibit

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