Z-Phe-Tyr(tBu)-diazomethylketone

Name: Z-Phe-Tyr(tBu)-diazomethylketone
Brand: MedChemExpress
SKU: HY-138208
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-138208 Reinheit: 98.04%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Z-Phe-Tyr(tBu)-diazomethylketone Chemische Struktur

CAS. Nr. : 114014-15-2

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

or Massenanfrage

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Z-Phe-Tyr(tBu)-diazomethylketone

•Cell. 2026 Feb 5;189(3):818-831.e19. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Cathepsin Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection^[1]^[2].

IC₅₀ & Target^[1]

cathepsin L

In Vitro

Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) resultes in reovirus inefficient proteolytic disassembly of viral outer-capsid proteins and decreases viral yields in L929 cells^[1].
Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection to about 10% of vehicle-treated controls in SARS-CoV-2 infection of cardiomyocytes (CMs)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

542.63

Formel

C₃₁H₃₄N₄O₅

CAS. Nr.

114014-15-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(C=[N+]=[N-])=O)CC(C=C1)=CC=C1OC(C)(C)C)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 250 mg/mL (460.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8429 mL	9.2144 mL	18.4288 mL
5 mM	0.3686 mL	1.8429 mL	3.6858 mL
10 mM	0.1843 mL	0.9214 mL	1.8429 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.04%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB) HNMR (298 KB) RP-HPLC (245 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. [Content Brief]

[2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8429 mL	9.2144 mL	18.4288 mL	46.0719 mL
	5 mM	0.3686 mL	1.8429 mL	3.6858 mL	9.2144 mL
	10 mM	0.1843 mL	0.9214 mL	1.8429 mL	4.6072 mL
	15 mM	0.1229 mL	0.6143 mL	1.2286 mL	3.0715 mL
	20 mM	0.0921 mL	0.4607 mL	0.9214 mL	2.3036 mL
	25 mM	0.0737 mL	0.3686 mL	0.7372 mL	1.8429 mL
	30 mM	0.0614 mL	0.3071 mL	0.6143 mL	1.5357 mL
	40 mM	0.0461 mL	0.2304 mL	0.4607 mL	1.1518 mL
	50 mM	0.0369 mL	0.1843 mL	0.3686 mL	0.9214 mL
	60 mM	0.0307 mL	0.1536 mL	0.3071 mL	0.7679 mL
	80 mM	0.0230 mL	0.1152 mL	0.2304 mL	0.5759 mL
	100 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.4607 mL