114014-15-2
114014-15-2
Chemical Structure
Z-Phe-Tyr(tBu)-diazomethylketone
- CAS No.: 114014-15-2
- Formula:C31H34N4O5
- Molecular Weight:542.63
IUPAC Name: benzyl ((S)-1-(((S)-1-(4-(tert-butoxy)phenyl)-4-diazo-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
InChIKey: CGONKNHDBTYOOC-SVBPBHIXSA-N
SMILES: O=C(N[C@H](C(C=[N+]=[N-])=O)CC(C=C1)=CC=C1OC(C)(C)C)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3
Biological Activity: Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Z-Phe-Tyr(tBu)-diazomethylketone | 99.61% | Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-P4306Z-Phe-Phe-Diazomethylketone -
Similarity Score 0.73
HY-128140Z-FY-CHO -
Similarity Score 0.72
HY-P4295Z-Phe-Ala-diazomethylketone -
Similarity Score 0.72
HY-115733Cathepsin L-IN-2 -
Similarity Score 0.72
HY-141867Z-FF-FMK -
Similarity Score 0.70
HY-114437Fusion Inhibitory Peptide -
Similarity Score 0.67
HY-W790014Z-FG-NHO-BzOME -
Similarity Score 0.65
HY-W010955Z-Phe-Leu-OH -
Similarity Score 0.65
HY-P0109(S,S)-Z-FA-FMK -
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References
- [1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. [Content Brief]
- [2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872. [Content Brief]
