Z-Phe-Tyr(tBu)-diazomethylketone

Name: Z-Phe-Tyr(tBu)-diazomethylketone
Brand: MedChemExpress
SKU: HY-138208
Rating: 4.5 (1 reviews)

製品番号: HY-138208 純度: 98.04%: Data Sheet SDS COA 取扱説明書
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Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Z-Phe-Tyr(tBu)-diazomethylketone 構造式

CAS 番号 : 114014-15-2

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 167	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 167	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$40	在庫あり	Estimated Time of Arrival: December 31
5 mg	$140	在庫あり	Estimated Time of Arrival: December 31
10 mg	$230	在庫あり	Estimated Time of Arrival: December 31
25 mg	$460	在庫あり	Estimated Time of Arrival: December 31
50 mg	$730	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1150	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Cell. 2026 Feb 5;189(3):818-831.e19. [Abstract]

Cathepsin アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection^[1]^[2].

IC₅₀ & Target^[1]

cathepsin L

体外実験

Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) resultes in reovirus inefficient proteolytic disassembly of viral outer-capsid proteins and decreases viral yields in L929 cells^[1].
Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection to about 10% of vehicle-treated controls in SARS-CoV-2 infection of cardiomyocytes (CMs)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

542.63

分子式

C₃₁H₃₄N₄O₅

CAS 番号

114014-15-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(C=[N+]=[N-])=O)CC(C=C1)=CC=C1OC(C)(C)C)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 250 mg/mL (460.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8429 mL	9.2144 mL	18.4288 mL
5 mM	0.3686 mL	1.8429 mL	3.6858 mL
10 mM	0.1843 mL	0.9214 mL	1.8429 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.04%

Select Batch:

データシート (272 KB) SDS (251 KB)

COA (250 KB) HNMR (298 KB) RP-HPLC (245 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. [Content Brief]

[2]. Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8429 mL	9.2144 mL	18.4288 mL	46.0719 mL
	5 mM	0.3686 mL	1.8429 mL	3.6858 mL	9.2144 mL
	10 mM	0.1843 mL	0.9214 mL	1.8429 mL	4.6072 mL
	15 mM	0.1229 mL	0.6143 mL	1.2286 mL	3.0715 mL
	20 mM	0.0921 mL	0.4607 mL	0.9214 mL	2.3036 mL
	25 mM	0.0737 mL	0.3686 mL	0.7372 mL	1.8429 mL
	30 mM	0.0614 mL	0.3071 mL	0.6143 mL	1.5357 mL
	40 mM	0.0461 mL	0.2304 mL	0.4607 mL	1.1518 mL
	50 mM	0.0369 mL	0.1843 mL	0.3686 mL	0.9214 mL
	60 mM	0.0307 mL	0.1536 mL	0.3071 mL	0.7679 mL
	80 mM	0.0230 mL	0.1152 mL	0.2304 mL	0.5759 mL
	100 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.4607 mL