2. Others NF-κB Immunology/Inflammation Anti-infection
  3. Biochemical Assay Reagents IKK NO Synthase Bacterial
  4. β-1,3-Glucan

β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors.

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β-1,3-Glucan

β-1,3-Glucan 화학구조

CAS No. : 9051-97-2

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고객리뷰

Based on 1 publication(s) in Google Scholar

β-1,3-Glucan Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE β-1,3-Glucan

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제품 설명

β-1,3-Glucan (β Glucan) is an orally active polysaccharide composed of glucose polymers. β-1,3-Glucan increase the activity of IKKβ kinase, enhances the production of nitric oxide. β-1,3-Glucan improves resistance to Vibrio harveyi infection. β-1,3-Glucan enhances immune response, promotes blood pressure recovery, reduces lung, kidney and liver damage, inhibits the growth of syngeneic tumors[1][2][3][4][5][6][7][8].

IC50 & Target[8]

IKKβ

 

In Vitro

β-1,3-Glucan (PGG-Glucan; 0.1-3 μg/mL; 3 h) can enhance the oxidative burst response of leukocytes to soluble and particulate activators and their microbicidal activity in a dose-dependent manner[1].
β-1,3-Glucan (0.5-5 mg/mL; 3 days) can significantly promote proliferation of L-929 fibroblasts[3].
β-1,3-Glucan can increase the activity of IKKβ kinase in the murine monocytic cell line J774a.1, and also enhance the production of nitric oxide and superoxide in murine peritoneal macrophages[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-1,3-Glucan Related Antibodies
In Vivo

β-1,3-Glucan (0.09%; added to the diet; p.o.; twice a day; 8 weeks) promotes the growth of large yellow croaker, enhances innate immunity and improves the resistance to Vibrio harveyi infection[2].
β-1,3-Glucan (40-160 mg/kg; p.o.; 5-10 days) enhances the proliferative response of spleen cells to mitogens, enhances the activity of natural killer cells and the lysosomal enzyme activity of peritoneal macrophages, and also inhibits the growth of syngeneic tumors in mice[4].
β-1,3-Glucan (20 mg/kg/day, p.o.; 2 mg/kg/day, s.c.; oral administration for 14 days, subcutaneous injection for 3 days) can promote the recovery of blood pressure, reduce kidney and liver injuries, and also regulate cytokine levels in a rat model of endotoxemia[5].
β-1,3-Glucan (2 mg/kg; i.m.; injected immediately after surgery and at 4 h after surgery) can improve the survival rate, reduce acute lung injury, inhibit the release of pro-inflammatory cytokines in a rat model of sepsis induced by cecal ligation and puncture (CLP)[6].
β-1,3-Glucan (250-1000 mg/kg; p.o.; once a day; 18 days) prevents myelosuppression and splenomegaly caused by tumors in tumor-bearing mice[7].
β-1,3-Glucan (150 mg/kg; p.o.; once daily; 7 days) can reverse the immunosuppression mediated by Aflatoxin B1 (HY-N6615), increase the percentages of lymphocyte subsets and the levels of multiple cytokines in the male adult Balb/c mouse model[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice, 6-8 weeks old, Ehrlich ascites tumour (EAT)-bearing model[7]
Dosage: 250 mg/kg, 500 mg/kg, 1000 mg/kg
Administration: Oral gavage, once a day for 18 days
Result: Significantly prolonged the lifespan of EAT-bearing mice.
Prevented myelosuppression and splenomegaly by increasing the number of granulocyte-macrophage progenitors in the bone marrow and increasing colony-stimulating activity in the serum.
Restored the ability of bone marrow stromal cells from tumor - bearing mice to display myeloid progenitors in long-term bone marrow cultures.
Upregulated the production of interleukin (IL)-6 and IL-1α by these cells.
Restored natural killer cell activity.
Clinical Trial
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[beta Glucan]
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

H2O : 40 mg/mL (ultrasonic and adjust pH to 12 with 1 M NaOH)

DMSO : 5 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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순도&문서

Purity: 98.18%

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β-1,3-Glucan Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-1,3-Glucan9051-97-2β GlucanBiochemical Assay ReagentsIKKNO SynthaseBacterialIκB kinaseI kappa B kinase Nitric oxide synthasesNOSL-929J774a.1Vibrio harveyilung injurymyelosuppressionimmunosuppressionInhibitorinhibitorinhibit

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β-1,3-Glucan
Cat. No.:
HY-W145521
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