DL-3-Phenyllactic acid

Name: DL-3-Phenyllactic acid
Brand: MedChemExpress
SKU: HY-W017162
Rating: 5.0 (2 reviews)

Art. -Nr.: HY-W017162 Reinheit: 99.92%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DL-3-Phenyllactic acid is a broad-spectrum antimicrobial compound.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr. : 828-01-3

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
100 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
5 g	Auf Lager	Estimated Time of Arrival: December 31
10 g	Angebot einholen
50 g	Angebot einholen

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Based on 2 publication(s) in Google Scholar

Other Forms of DL-3-Phenyllactic acid:

DL-3-Phenyllactic acid-d₃ In-stock
DL-3-Phenyllactic acid (Standard) In-stock

2 Publications Citing Use of MCE DL-3-Phenyllactic acid

Bio/Physico-chemical Assay

RT-PCR

: DL-3-Phenyllactic acid purchased from MedChemExpress. Usage Cited in: Viruses. 2024 Mar 13;16(3):449. [Abstract]; DL-3-Phenyllactic acid (PLA) (2 μM; 24 h) significantly reduced the consumption of glutamine and glucose of PAM cells.

: DL-3-Phenyllactic acid purchased from MedChemExpress. Usage Cited in: Viruses. 2024 Mar 13;16(3):449. [Abstract]; DL-3-Phenyllactic acid (PLA) (2 μM; 24 h) significantly downregulated the transcription levels of the ASFV-P72 gene in PAM cells.

: DL-3-Phenyllactic acid purchased from MedChemExpress. Usage Cited in: Viruses. 2024 Mar 13;16(3):449. [Abstract]; DL-3-Phenyllactic acid (PLA) (2-10 μM; 24 h) significantly downregulated the protein expression levels of the ASFV-P72 gene in PAM cells.

: DL-3-Phenyllactic acid purchased from MedChemExpress. Usage Cited in: Viruses. 2024 Mar 13;16(3):449. [Abstract]; DL-3-Phenyllactic acid (PLA) (2 μM; 24 h) reduce the number of progeny virions in PAM cells.

: DL-3-Phenyllactic acid purchased from MedChemExpress. Usage Cited in: Viruses. 2024 Mar 13;16(3):449. [Abstract]; DL-3-Phenyllactic acid (PLA) (2 μM; 24 h) significantly reduced the transcription level of SLC1A5 and the enzyme activity of GLS but did not significantly change the transcription level of GLS in PAM cells.

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Human Endogenous Metabolite Microbial Metabolite

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

DL-3-Phenyllactic acid is a broad-spectrum antimicrobial compound.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	> 100 6 Compound: 12	Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay	[PMID: 21546250]
Jurkat	IC₅₀	>100 6 Compound: 12	Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay	[PMID: 21546250]
Jurkat	IC₅₀	> 100 6 Compound: 12	Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay Cytotoxicity against human Jurkat T cells after 36 hrs by MTT assay	[PMID: 21546250]

In Vitro

DL-3-Phenyllactic acid (3-Phenyllactic acid, PLA), which is an organic acid widely existing in honey and lactic acid bacteria fermented food, can be produced by many microorganisms, especially lactic acid bacteria. DL-3-Phenyllactic acid is proved as an ideal antimicrobial compound with broad and effective antimicrobial activity against both bacteria and fungi. In addition, DL-3-Phenyllactic acid can be used as feed additives to replace antibiotics in livestock feeds^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

166.18

Formel

C₉H₁₀O₃

CAS. Nr.

828-01-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(O)CC1=CC=CC=C1

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (601.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 33.33 mg/mL (200.57 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0177 mL	30.0886 mL	60.1772 mL
5 mM	1.2035 mL	6.0177 mL	12.0354 mL
10 mM	0.6018 mL	3.0089 mL	6.0177 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (12.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (12.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (12.52 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.92%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) HNMR (140 KB) RP-HPLC (255 KB) MS (174 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Mu W, et al. Recent research on 3-phenyllactic acid, a broad-spectrum antimicrobial compound. Appl Microbiol Biotechnol. 2012 Sep;95(5):1155-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	6.0177 mL	30.0886 mL	60.1772 mL	150.4429 mL
	5 mM	1.2035 mL	6.0177 mL	12.0354 mL	30.0886 mL
	10 mM	0.6018 mL	3.0089 mL	6.0177 mL	15.0443 mL
	15 mM	0.4012 mL	2.0059 mL	4.0118 mL	10.0295 mL
	20 mM	0.3009 mL	1.5044 mL	3.0089 mL	7.5221 mL
	25 mM	0.2407 mL	1.2035 mL	2.4071 mL	6.0177 mL
	30 mM	0.2006 mL	1.0030 mL	2.0059 mL	5.0148 mL
	40 mM	0.1504 mL	0.7522 mL	1.5044 mL	3.7611 mL
	50 mM	0.1204 mL	0.6018 mL	1.2035 mL	3.0089 mL
	60 mM	0.1003 mL	0.5015 mL	1.0030 mL	2.5074 mL
	80 mM	0.0752 mL	0.3761 mL	0.7522 mL	1.8805 mL
	100 mM	0.0602 mL	0.3009 mL	0.6018 mL	1.5044 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.