3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles

Cat. No.: HY-142042 Pureza: 99.84%: Ficha de datos
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3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC₅₀ of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model.

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3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles Estructura química

No. CAS : 287196-91-2

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
100 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas MEK:

Ver todas las isoformas

MEK1 MEK2 MEK5 MEK MAP2K4/MEK4 MAP2K7/MEK7

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Peso molecular

285.25

Fòrmula

C₁₁H₆F₃N₃OS

No. CAS

287196-91-2

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(NC2=CC=CC=C2C(F)(F)F)SNC1=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 250 mg/mL (876.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5057 mL	17.5285 mL	35.0570 mL
5 mM	0.7011 mL	3.5057 mL	7.0114 mL
10 mM	0.3506 mL	1.7528 mL	3.5057 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.84%

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Ficha de datos (275 KB) SDS (251 KB)

COA (253 KB) HNMR (257 KB) LCMS (94 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Arnon KARNI, Small organic molecules for use in the treatment of neuroinflammatory disorders. WO2018198123.

[2]. Varaprasad CV, et al., Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5057 mL	17.5285 mL	35.0570 mL	87.6424 mL
	5 mM	0.7011 mL	3.5057 mL	7.0114 mL	17.5285 mL
	10 mM	0.3506 mL	1.7528 mL	3.5057 mL	8.7642 mL
	15 mM	0.2337 mL	1.1686 mL	2.3371 mL	5.8428 mL
	20 mM	0.1753 mL	0.8764 mL	1.7528 mL	4.3821 mL
	25 mM	0.1402 mL	0.7011 mL	1.4023 mL	3.5057 mL
	30 mM	0.1169 mL	0.5843 mL	1.1686 mL	2.9214 mL
	40 mM	0.0876 mL	0.4382 mL	0.8764 mL	2.1911 mL
	50 mM	0.0701 mL	0.3506 mL	0.7011 mL	1.7528 mL
	60 mM	0.0584 mL	0.2921 mL	0.5843 mL	1.4607 mL
	80 mM	0.0438 mL	0.2191 mL	0.4382 mL	1.0955 mL
	100 mM	0.0351 mL	0.1753 mL	0.3506 mL	0.8764 mL