287196-91-2
Chemical Structure
3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles
- CAS No.: 287196-91-2
- Formula:C11H6F3N3OS
- Molecular Weight:285.25
IUPAC Name: 3-oxo-5-((2-(trifluoromethyl)phenyl)amino)-2,3-dihydroisothiazole-4-carbonitrile
InChIKey: RVAGAHLIJPXBEV-UHFFFAOYSA-N
SMILES: N#CC1=C(NC2=CC=CC=C2C(F)(F)F)SNC1=O
Biological Activity: 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles | 99.84% | 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model. | ||||||||||||||||||||
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References
- [1]. Arnon KARNI, Small organic molecules for use in the treatment of neuroinflammatory disorders. WO2018198123.
- [2]. Varaprasad CV, et al., Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. [Content Brief]
