Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors

  • Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. doi: 10.1016/j.bmcl.2006.05.019.
Chamakura V N S Varaprasad  1 ,  Dinesh Barawkar ,  Hassan El Abdellaoui ,  Subrata Chakravarty ,  Matthew Allan ,  Huanming Chen ,  Weijian Zhang ,  Jim Z Wu ,  Robert Tam ,  Robert Hamatake ,  Stanley Lang ,  Zhi Hong
Affiliations
  • 1. Drug Discovery, Valeant Pharmaceutical Research and Development, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. [email protected]
PMID: 16725322 DOI: 10.1016/j.bmcl.2006.05.019
Abstract

3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles were discovered as potent in vitro MEK1 inhibitors.

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