AKBA (Synonyms: Acetyl-11-keto-β-boswellic acid)

Name: AKBA
Brand: MedChemExpress
SKU: HY-N0892
Rating: 5.0 (3 reviews)

Cat. No.: HY-N0892 Purity: 99.92%: Data Sheet
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AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

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AKBA 화학구조

CAS No. : 67416-61-9

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of AKBA:

AKBA (Standard) In-stock

3 Publications Citing Use of MCE AKBA

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View All Isoforms

HIF-1α HIF

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Human Endogenous Metabolite Microbial Metabolite

Biological Activity
순도&문서
고객리뷰

제품 설명

AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	14.1 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
A549	IC₅₀	3 μM Compound: 4	Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis	[PMID: 24844534]
DLD-1	IC₅₀	20.9 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human DLD1 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human DLD1 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
HCT-8	IC₅₀	17.5 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human HCT8 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human HCT8 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
HL-60	IC₅₀	11 μM Compound: 4, AKBA	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 21334793]
HT-29	IC₅₀	19.4 μM Compound: 4, (beta-AKBA)	Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 25618017]
HUVEC	IC₅₀	7.45 μM Compound: 1, AKBA	Antiproliferation activity against HUVEC cells after 48 hrs by CCK-8 assay Antiproliferation activity against HUVEC cells after 48 hrs by CCK-8 assay	[PMID: 25819335]
HeLa	IC₅₀	31 μM Compound: 4, AKBA	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21334793]
LNCaP	GI₅₀	27.43 μM Compound: AKBA	Anti-proliferative activity against human LNCAP cells measured after 96 hrs by MTT assay Anti-proliferative activity against human LNCAP cells measured after 96 hrs by MTT assay	[PMID: 27997878]
PC-3	GI₅₀	31.86 μM Compound: AKBA	Anti-proliferative activity against human PC3 cells measured after 96 hrs by MTT assay Anti-proliferative activity against human PC3 cells measured after 96 hrs by MTT assay	[PMID: 27997878]
PC-3	GI₅₀	31.9 μM Compound: 1; AKBA	Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay	[PMID: 30153964]
RAW264.7	IC₅₀	15.6 μM Compound: AKBA	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs	[PMID: 23391590]
Sf21	IC₅₀	> 40 μM Compound: 29	Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis	[PMID: 31774676]

In Vitro

AKBA (Acetyl-11-keto-β-boswellic acid) significantly reduced infarct volumes and apoptotic cells, and also increased neurologic scores by elevating the Nrf2 and HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 and HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE)^[1].
AKBA (Acetyl-11-keto-β-boswellic acid) significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis^[3].
AKBA (Acetyl-11-keto-β-boswellic acid) triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL), and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA (Acetyl-11-keto-β-boswellic acid) treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AKBA (Acetyl-11-keto-β-boswellic acid) significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA's activity both in the prevention of small intestinal and colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA's effect, that is the reduction of polyp size and degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon^[1].
AKBA (Acetyl-11-keto-β-boswellic acid) administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin^[3].
AKBA (Acetyl-11-keto-β-boswellic acid) exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

512.72

화학식

C₃₂H₄₈O₅

CAS No.

67416-61-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@@](C1=C2)(CC[C@@](C)(CC[C@H]3C)[C@@]1([H])[C@H]3C)C)(CC[C@@]4([H])[C@@]5(C)C(O)=O)[C@@](C2=O)([H])[C@]4(CC[C@H]5OC(C)=O)C

Structure Classification

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : ≥ 5.2 mg/mL (10.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9504 mL	9.7519 mL	19.5038 mL
5 mM	0.3901 mL	1.9504 mL	3.9008 mL
10 mM	0.1950 mL	0.9752 mL	1.9504 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

순도&문서

Purity: 99.92%

Select Batch:

Data Sheet (252 KB) SDS (393 KB)

COA (252 KB) HNMR (285 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9504 mL	9.7519 mL	19.5038 mL	48.7596 mL
	5 mM	0.3901 mL	1.9504 mL	3.9008 mL	9.7519 mL
	10 mM	0.1950 mL	0.9752 mL	1.9504 mL	4.8760 mL

AKBA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKBA67416-61-9Acetyl-11-keto-β-boswellic acidHIF/HIF Prolyl-HydroxylaseReactive Oxygen Species (ROS)Endogenous MetaboliteHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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AKBA (Synonyms: Acetyl-11-keto-β-boswellic acid)

고객리뷰

Other Forms of AKBA:

AKBA Related Antibodies

3 Publications Citing Use of MCE AKBA

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HIF/HIF Prolyl-Hydroxylase Isoform Specific Products:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

순도&문서

고객리뷰

AKBA Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

AKBA Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report