2. Apoptosis Metabolic Enzyme/Protease
  3. MDM-2/p53 HIF/HIF Prolyl-Hydroxylase
  4. Amifostine

Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action.

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CAS. Nr. : 20537-88-6

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Based on 13 publication(s) in Google Scholar

Other Forms of Amifostine:

Amifostine Related Antibodies

Top Publications Citing Use of Products

    Amifostine purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Feb 13;6(2):e70092.  [Abstract]

    The dynamics of the numbers of CFUs in the bone marrow from indicated groups within a month post‐irradiation. The results showed that the reduction in colony-forming unit (CFU) counts in mice treated with Amifostine (150 mg/kg; i.p.; single dose) was relatively mild at 7 days post-irradiation.

    Amifostine purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58.  [Abstract]

    HE staining of testis among the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

    Amifostine purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58.  [Abstract]

    Protein level alterations of Bclaf1, P-Rela, Rela, Sycp3, and β-actin were analyzed among the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

    Amifostine purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2025 Jan 31;23(1):58.  [Abstract]

    RT-qPCR analysis of Spliceosome-related gene expression levels across the control group, IR group, Amifostine (50 mg/kg; i.p.) group, NF-κB activator 2 group, and CU-T12-9 group.

    Amifostine purchased from MedChemExpress. Usage Cited in: Bioact Mater.2024 May 21:39:191-205.  [Abstract]

    Cell viabilities of A31 cells under different doses of IR (0, 2, 4, 6, 8, and 10 Gy) with pretreatment of tFNAs, Amifostine (AMF, 54 μg/mL; 12 h), or nanosuit (250 nM; 12 h) (n = 5).

    Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen:

    Alle Isoformen anzeigen
    HIF-1α HIF

    • Biologische Aktivität

    • Reinheit & Dokumentation

    • Verweise

    • Kundenbewertung

    Beschreibung

    Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[1][2][3][4].

    In Vitro

    Amifostine (0.78125-100 μM, 24 h) reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Amifostine Related Antibodies
    In Vivo

    Amifostine (i.v., 400 mg/kg, 4 h) has a protective effect against myocardial I/R injury in male C57BL/6 mice[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice with myocardial I/R injury[5]
    Dosage: 400 mg/kg
    Administration: Intravenous injection; 4 hours
    Result: Attenuated cardiomyocyte apoptosis and reduced the production of I/R-induced ROS.
    Significantly reduced the expression of cleaved caspase 3 and Bax while enhanced the expression of SOD1, SOD2 and Bcl2.
    Significantly increased SOD activity and reduced MDA levels.
    Klinische Studie
    Molekulargewicht

    214.22

    Formel

    C5H15N2O3PS
    CAS. Nr.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OP(SCCNCCCN)(O)=O
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Lösungsmittel & Löslichkeit
    In Vitro: 

    H2O : 100 mg/mL (466.81 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.6681 mL 23.3405 mL 46.6810 mL
    5 mM 0.9336 mL 4.6681 mL 9.3362 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molaritätsrechner

    • Verdünnungsrechner

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (466.81 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Reinheit & Dokumentation

    Purity: 99.95%

    SDS (392 KB)

    COA (242 KB) HNMR (213 KB) CNMR (219 KB) RP-HPLC (167 KB) MS (85 KB)

    Handling Instructions (2659 KB)
    Verweise

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.6681 mL 23.3405 mL 46.6810 mL 116.7025 mL
    5 mM 0.9336 mL 4.6681 mL 9.3362 mL 23.3405 mL
    10 mM 0.4668 mL 2.3340 mL 4.6681 mL 11.6702 mL
    15 mM 0.3112 mL 1.5560 mL 3.1121 mL 7.7802 mL
    20 mM 0.2334 mL 1.1670 mL 2.3340 mL 5.8351 mL
    25 mM 0.1867 mL 0.9336 mL 1.8672 mL 4.6681 mL
    30 mM 0.1556 mL 0.7780 mL 1.5560 mL 3.8901 mL
    40 mM 0.1167 mL 0.5835 mL 1.1670 mL 2.9176 mL
    50 mM 0.0934 mL 0.4668 mL 0.9336 mL 2.3340 mL
    60 mM 0.0778 mL 0.3890 mL 0.7780 mL 1.9450 mL
    80 mM 0.0584 mL 0.2918 mL 0.5835 mL 1.4588 mL
    100 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1670 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Amifostine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Amifostine20537-88-6WR2721WR 2721WR-2721MDM-2/p53HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHBroad-spectrumradioprotectorcytoprotectivethiolantiangiogenicHIF-α1p53DNA-damageInhibitorinhibitorinhibit

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