2. Metabolic Enzyme/Protease
  3. Liposome Endogenous Metabolite
  4. DPPC

DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice.

For research use only. We do not sell to patients.

CAS No. : 63-89-8

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Solution
10 mM * 1 mL in Ethanol In-stock
Solid
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Based on 9 publication(s) in Google Scholar

Other Forms of DPPC:

DPPC Related Antibodies

Top Publications Citing Use of Products

    DPPC purchased from MedChemExpress. Usage Cited in: Biol Direct. 2023 Oct 24;18(1):67.  [Abstract]

    The activation of ERK1/2-CREB pathway and NRF1 protein levels after LPCAT1 knockdown and DPPC (10 μM) supplementation were analysed by Western blot.

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    Description

    DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice[1][2][3][4][5].

    IC50 & Target

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    In Vitro

    DPPC (2-10 mg/ml) monolayer can be inserted by Aβ40, but the amount of insertion is smaller than that of DPPG or DPTAP. The behavior of Aβ40 inserted into the DPPC monolayer is affected by surface pressure, solvent (water or PBS), and salt concentration[3].
    DPPC can mix with DPPE to form DPPC/DPPE lipid bilayer systems. As DPPE concentration rises, the average area per headgroup diminishes (0.65 to 0.52 nm²), enhancing membrane compactness. Meanwhile, membrane thickness slightly increases (3.43 to 4.00 nm), reflecting lipid tail ordering. [5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    DPPC Related Antibodies
    In Vivo

    DPPC（0.5 μmol, 7 days) can serve as a critical component that enhances the stability of lipid membrane structures in liposome construction. GSL antigen was virtually non-immunogenic by itself, but GSL antigen-containing DMPC-liposome can enhance the immunogenicity of GSL antigen in mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female BALB/c mice (6-week-old)
    Dosage: 0.05 μmol
    Administration: Intraperitoneally immunized
    Result: DPPC-liposome would serve effectively as a delivery vehicle for inducing immune responses against GSL antigen. DPPC-liposome combined with GSL antigens was more effective than GSLs reconstituted in either DMPC- or DSPC-liposome [2].
    Molecular Weight

    734.04

    Formula

    C40H80NO8P
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    Ethanol : 25 mg/mL (34.06 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3623 mL 6.8116 mL 13.6232 mL
    5 mM 0.2725 mL 1.3623 mL 2.7246 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (3.41 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (3.41 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    Dosing volume
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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.91%

    SDS (647 KB)

    COA (243 KB) HNMR (302 KB) RP-HPLC (281 KB) MS (97 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol 1 mM 1.3623 mL 6.8116 mL 13.6232 mL 34.0581 mL
    5 mM 0.2725 mL 1.3623 mL 2.7246 mL 6.8116 mL
    10 mM 0.1362 mL 0.6812 mL 1.3623 mL 3.4058 mL
    15 mM 0.0908 mL 0.4541 mL 0.9082 mL 2.2705 mL
    20 mM 0.0681 mL 0.3406 mL 0.6812 mL 1.7029 mL
    25 mM 0.0545 mL 0.2725 mL 0.5449 mL 1.3623 mL
    30 mM 0.0454 mL 0.2271 mL 0.4541 mL 1.1353 mL
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    DPPC Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DPPC63-89-8129Y83LiposomeEndogenous MetaboliteLiposomesGSL antigenDelivery systemsImmunogenicityInhibitorinhibitorinhibit

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