2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Reactive Oxygen Species (ROS)
  4. Glutathione oxidized

Glutathione oxidized  (Synonyms: L-Glutathione oxidized; GSSG; Oxiglutatione)

Cat. No.: HY-D0844 Purity: 98.88%
COA
SDS
Handling Instructions Technical Support

Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 27025-41-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
500 mg In-stock
1 g In-stock
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10 g   Get quote  

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Based on 8 publication(s) in Google Scholar

Other Forms of Glutathione oxidized:

Glutathione oxidized Related Antibodies

Top Publications Citing Use of Products

    Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2024 Dec 31:111368.  [Abstract]

    DFO (100 μM，24 h) and GSH (2 mM, 24 h) reversed the inhibition of Sal on MGC803 cell viability.

    Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19.  [Abstract]

    The fluorescence intensity of MMP-2 in the HFSFs treated with glutathione oxidized (GLU, 2.48 mg/mL, 24 h) was 2.09 times greater than that in the HFSFs treated with ARP-100 (ARP, 100 μM, 24 h).

    Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19.  [Abstract]

    The MMP-2 mRNA level in the HFSFs treated with glutathione oxidized (GLU, 2.48 mg/mL, 24 h) was 2.46 times greater than that in the ARP-100 (ARP, 100 μM, 24 h)-treated HFSFs.

    Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19.  [Abstract]

    IF analysis revealed a notable increase in collagen I fluorescence intensity in the HFSFs treated with ARP-100 (ARP, 100 μM, 24 h), whereas a reduction in collagen I fluorescence intensity was found in HFSFs treated with glutathione oxidized (GLU, 2.48 mg/mL, 24 h).

    Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19.  [Abstract]

    WB analysis of MMP-2 and collagen I expression in HFSFs following treatment with ARP-100 (ARP, 100 μM), glutathione oxidized (GLU, 2.48 mg/mL), or PBS for 24 hours.

    Glutathione oxidized purchased from MedChemExpress. Usage Cited in: Invest Ophthalmol Vis Sci. 2025 May 1;66(5):19.  [Abstract]

    Compared with guinea pigs receiving periocular injections of vehicle (5 mM, 10 μL on days 1, 4, 7, 10, and 13 over two weeks), those treated with glutathione oxidized (Glu, 20 mg/mL, 10 μL on the same schedule) exhibited a 1.76-fold increase in relative myopia, along with a 1.78-fold increase in axial length (AL).

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Increased efflux of Glutathione oxidized leads to glutathione depletion and may weaken the antioxidant defense of sickle erythrocytes[1].
    Glutathione oxidized (400 μM) inhibits epithelial sodium channel activity in primary alveolar epithelial T2 cells[2].
    Glutathione oxidized will self-assemble to form a gel at high concentrations and should be used as soon as possible and avoid prolonged ultrasonic treatment. Self-assembly will not occur at low concentrations (such as 8 mM).

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Glutathione oxidized Related Antibodies
    Molecular Weight

    612.63

    Formula

    C20H32N6O12S2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    γGlu-Cys-Gly (Cys dimer)
    Sequence Shortening

    γGlu-CG (Cys dimer)
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 200 mg/mL (326.46 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6323 mL 8.1615 mL 16.3231 mL
    5 mM 0.3265 mL 1.6323 mL 3.2646 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (163.23 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.0%

    SDS (396 KB)

    COA (250 KB) HNMR (131 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.6323 mL 8.1615 mL 16.3231 mL 40.8077 mL
    5 mM 0.3265 mL 1.6323 mL 3.2646 mL 8.1615 mL
    10 mM 0.1632 mL 0.8162 mL 1.6323 mL 4.0808 mL
    15 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7205 mL
    20 mM 0.0816 mL 0.4081 mL 0.8162 mL 2.0404 mL
    25 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
    30 mM 0.0544 mL 0.2721 mL 0.5441 mL 1.3603 mL
    40 mM 0.0408 mL 0.2040 mL 0.4081 mL 1.0202 mL
    50 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8162 mL
    60 mM 0.0272 mL 0.1360 mL 0.2721 mL 0.6801 mL
    80 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5101 mL
    100 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4081 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Glutathione oxidized Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Glutathione oxidized27025-41-8L-Glutathione oxidized GSSG OxiglutationeEndogenous MetaboliteReactive Oxygen Species (ROS)sickle cellerythrocyteglutathioneROSDMNQInhibitorinhibitorinhibit

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