2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Hypoxanthine

ヒポキサンチン  (Synonyms: Hypoxanthine; Purin-6-ol; Sarcine)

製品番号: HY-N0091 純度: 99.96%
COA 取扱説明書 Technical Support

Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 68-94-0

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
50 mg $50 在庫あり
100 mg $60 在庫あり
500 mg $140 在庫あり
1 g $210 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 15 publication(s) in Google Scholar

Other Forms of Hypoxanthine:

ヒポキサンチン 関連抗体

Top Publications Citing Use of Products

    Hypoxanthine purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Sep 29:634:218069.  [Abstract]

    Relative cell viability of PC-9 cells supplementing with inosine, adenosine, or hypoxanthine treated with osimertinib for 120 h.

    Hypoxanthine purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 May;44(16):1078-1092.  [Abstract]

    MHCC-97H cells with or without depletion of GART were treated with or without exogenous hypoxanthine (100 mM). Cell viability was examined by CCK-8 assay.

    Hypoxanthine purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 21;22(1):192.  [Abstract]

    Rescue experiments using exogenous supplementation of hypoxanthine (100 µM) and GSH in ZSWIM4-knockdown OVCAR8 cells.

    Hypoxanthine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncolytics. 2021 Aug 28:23:107-123.

    DNA replication arrest of cancer cells induced by OA treatment (200 mM) was restored by exogenous supplementation of hypoxanthine (Hyp) (100 mM) (E) for 8 h.

    Hypoxanthine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncolytics. 2021 Aug 28:23:107-123.

    Proliferating cell nuclear antigen (PCNA) expression induced by 200 mM OA treatment was recovered by exogenous supplementation of inosine or hypoxanthine (Hyp) (100 mM).

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    A-431 IC50
    >100 μg/mL
    Compound: hypoxanthine
    Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
    Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
    		[PMID: 1666120]
    体外実験

    Hypoxanthine is a potential free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury through oxygen radical production and is therefore involved in the pathogenesis of a number of diseases. Hypoxanthine also modulates a number of other processes because it reacts with benzodiazepine receptors and inhibits phosphodiesterase in the brain. Hypoxanthine inhibits the effect of several cytotoxic drugs and may therefore influence treatment with such drugs[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ヒポキサンチン 関連抗体
    体内実験

    In pigs, a linear increase of plasma hypoxanthine with duration of hypoxemia is found, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. There is also a direct relationship between survival time and increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62).All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine therefore reflected the prognosis of acute hypoxia in contrast to base deficit[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    136.11

    分子式

    C5H4N4O
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to pink

    SMILES

    O=C1NC=NC2=C1N=CN2
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 10 mg/mL (73.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 7.3470 mL 36.7350 mL 73.4700 mL
    5 mM 1.4694 mL 7.3470 mL 14.6940 mL
    10 mM 0.7347 mL 3.6735 mL 7.3470 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1 mg/mL (7.35 mM); Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 1 mg/mL (7.35 mM); Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 25 mg/mL (183.67 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.96%

    COA (252 KB) HNMR (131 KB) RP-HPLC (336 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 7.3470 mL 36.7350 mL 73.4700 mL 183.6750 mL
    5 mM 1.4694 mL 7.3470 mL 14.6940 mL 36.7350 mL
    10 mM 0.7347 mL 3.6735 mL 7.3470 mL 18.3675 mL
    15 mM 0.4898 mL 2.4490 mL 4.8980 mL 12.2450 mL
    20 mM 0.3673 mL 1.8367 mL 3.6735 mL 9.1837 mL
    25 mM 0.2939 mL 1.4694 mL 2.9388 mL 7.3470 mL
    30 mM 0.2449 mL 1.2245 mL 2.4490 mL 6.1225 mL
    40 mM 0.1837 mL 0.9184 mL 1.8367 mL 4.5919 mL
    50 mM 0.1469 mL 0.7347 mL 1.4694 mL 3.6735 mL
    60 mM 0.1224 mL 0.6122 mL 1.2245 mL 3.0612 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Hypoxanthine Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Hypoxanthine68-94-0Purin-6-ol SarcineEndogenous MetaboliteInhibitorinhibitorinhibit

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    製品名:
    Hypoxanthine
    製品番号:
    HY-N0091
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