2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Indolelactic acid

Indolelactic acid  (Synonyms: Indole-3-lactic acid)

製品番号: HY-113099 純度: 99.95%
COA 取扱説明書 Technical Support

Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity.

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CAS 番号 : 1821-52-9

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 49 在庫あり
Solution
10 mM * 1 mL in DMSO USD 49 在庫あり
Solid
5 mg $45 在庫あり
10 mg $70 在庫あり
25 mg $130 在庫あり
50 mg $210 在庫あり
100 mg $357 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 14 publication(s) in Google Scholar

Other Forms of Indolelactic acid:

Indolelactic acid 関連抗体

Top Publications Citing Use of Products

    Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165.  [Abstract]

    Cell growth curves of colorectal cancer (CRC) cell line HCT116 cells treated with Indolelactic acid (2 μM; 2 days) and a vehicle (as negative control).

    Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165.  [Abstract]

    HCT116 cells treated with or without Indolelactic acid (2 μM; 12 h) were stained with propidium iodide (PI) and analyzed using flow cytometry.

    Indolelactic acid purchased from MedChemExpress. Usage Cited in: Imeta. 2024 Jan 15;3(1):e165.  [Abstract]

    Expression levels of cell proliferation and cell cycle-associated proteins and gut barrier function-associated proteins in HCT116 cells treated with or without Indolelactic acid (2 μM; 12 h).

    Indolelactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Apr 22;14(7):2719-2735.  [Abstract]

    Colitis-associated colorectal cancer (CAC) mice treate PBS, Indolelactic acid (ILA) (20 mg/kg/daily by oral gavage) and ILA+CH-223191. Representative colonic images and statistical histogram of colon length.

    Indolelactic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Apr 22;14(7):2719-2735.  [Abstract]

    Gene expression of Il1b, Tnf, and Il10 in murine BMDMs treated Indolelactic acid (ILA) (0-1000 μM) and ILA+CH-223191.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity[1][3][4].

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    Sf9 IC50
    0.22 mM
    Compound: DL-indole-3-lactic acid
    Inhibition of human recombinant KAT1 expressed in Sf9 cells
    Inhibition of human recombinant KAT1 expressed in Sf9 cells
    		[PMID: 19338303]
    体外実験

    Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells[2].
    Indolelactic acid (0.1-10 mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells[3].
    Indolelactic acid (0.1-10 mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells[3].
    Indolelactic acid (10 mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells[3].
    Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Indolelactic acid 関連抗体

    RT-PCR[3]

    Cell Line: HT-29 cells
    Concentration: 0.1, 1, 10 mM
    Incubation Time: 1 h
    Result: Decreased IL-8 level induced by TNF-α, and increased β-defensin 2 and SERT level.
    体内実験

    Indolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6 mice[4]
    Dosage: 10 μM, 5 μL
    Administration: Gavage feeding, 5 days
    Result: Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.
    分子量

    205.21

    分子式

    C11H11NO3
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    OC(C(CC1=CNC2=CC=CC=C12)O)=O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (487.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.8730 mL 24.3649 mL 48.7299 mL
    5 mM 0.9746 mL 4.8730 mL 9.7460 mL
    10 mM 0.4873 mL 2.4365 mL 4.8730 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

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    濃度 （終了）

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    体積 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (10.14 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (10.14 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 20 mg/mL (97.46 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.95%

    COA (254 KB) HNMR (248 KB) RP-HPLC (221 KB) LCMS (93 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.8730 mL 24.3649 mL 48.7299 mL 121.8246 mL
    5 mM 0.9746 mL 4.8730 mL 9.7460 mL 24.3649 mL
    10 mM 0.4873 mL 2.4365 mL 4.8730 mL 12.1825 mL
    15 mM 0.3249 mL 1.6243 mL 3.2487 mL 8.1216 mL
    20 mM 0.2436 mL 1.2182 mL 2.4365 mL 6.0912 mL
    25 mM 0.1949 mL 0.9746 mL 1.9492 mL 4.8730 mL
    30 mM 0.1624 mL 0.8122 mL 1.6243 mL 4.0608 mL
    40 mM 0.1218 mL 0.6091 mL 1.2182 mL 3.0456 mL
    50 mM 0.0975 mL 0.4873 mL 0.9746 mL 2.4365 mL
    60 mM 0.0812 mL 0.4061 mL 0.8122 mL 2.0304 mL
    80 mM 0.0609 mL 0.3046 mL 0.6091 mL 1.5228 mL
    100 mM 0.0487 mL 0.2436 mL 0.4873 mL 1.2182 mL
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    Indolelactic acid Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Indolelactic acid1821-52-9Indole-3-lactic acidEndogenous MetaboliteTh2 cellmacrophagesHT-29Caco-2RAWinflammationgalectin-1Inhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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