L-Lysine hydrochloride

Name: L-Lysine hydrochloride
Brand: MedChemExpress
SKU: HY-N0470
Rating: 5.0 (9 reviews)

Cat. No.: HY-N0470 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

For research use only. We do not sell to patients.

CAS No. : 657-27-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of L-Lysine hydrochloride:

L-Lysine-¹⁵N₂ hydrochloride In-stock
L-Lysine-¹³C dihydrochloride In-stock
L-Lysine-¹³C₆,¹⁵N₂ hydrochloride In-stock
L-Lysine-d₈ hydrochloride In-stock
L-Lysine-d₉ hydrochloride In-stock
L-Lysine-d₄ hydrochloride In-stock
L-Lysine-¹³C₆ hydrochloride In-stock
L-Lysine In-stock
L-Lysine acetate In-stock
L-Lysine hydrate In-stock
L-Lysine-d₃ hydrochloride Get quote
L-Lysine-¹³C₆,¹⁵N₂,d₉ dihydrochloride Get quote
L-Lysine hydrochloride (Standard) Get quote

9 Publications Citing Use of MCE L-Lysine hydrochloride

In Vivo Efficacy Study

Cell Migration/Invasion Assay

Microbiological Assay

: L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.; Serum FITC-dextran levels were reduced upon L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation, indicating improved barrier function. L-Lysine also partially reversed the weight loss.

: L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.; Representative immunofluorescence images of ZO-1 and red mean density analysis of ZO-1 in the ileum and colon. L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation significantly restored ZO-1 density.

: L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.; Effect of L-Lysine (1.4 mM; 12 h) intervention on the scratch injury healing rate of IFN-γ pre-processed and NCM-460 cells. IFN‐γ significantly impaired healing in NCM-460 cells, and this effect was significantly alleviated by L‐Lysine.

: L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.; Effects of L-Lysine (1.4 mM; 24 h) intervention on the ZO-1 and Occludin expression of IFN-γ pre-processed HIEC-6 cells by western blot.

: L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.; L-Lysine (0.7-2.8 mM) dose-dependently inhibits H.biformis growth in vitro.

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Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vivo

L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhances antioxidant activity. Pre- or post-treatment with L-lysine leads to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement is observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione^[1]. L-lysine supplementation almost completely ameliorates vascular calcification. Dietary L-lysine strongly suppresses plasma intact parathyroid hormone in adenine rats and supports a proper bone-vascular axis. The conserved orientation of the femoral apatite in group Lys also evidences the bone-protective effects of L-lysine. Dietary L-lysine elevates plasma alanine, proline, arginine, and homoarginine but not lysine^[2]. The dose-dependent delay in gastric emptying observed in rats is confirmed in humans with an increase in halftime of gastric emptying of 4 min/g L-lysine. Moreover, a dose-dependent increase in intestinal fluid accumulation is observed (0.4 mL/min/g L-lysine)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

182.65

Formula

C₆H₁₅ClN₂O₂

CAS No.

657-27-2

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CCCCN)C(O)=O.[H]Cl

Structure Classification

Amino acids

Initial Source

Animals

Microorganisms

a genetically modified strain of Escherichia coli.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (547.50 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4750 mL	27.3748 mL	54.7495 mL
5 mM	1.0950 mL	5.4750 mL	10.9499 mL
10 mM	0.5475 mL	2.7375 mL	5.4750 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (273.75 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (244 KB) HNMR (130 KB) LCMS (325 KB)

Handling Instructions (2659 KB)

References

[1]. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]

[2]. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009. [Content Brief]

[3]. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [Content Brief]

Animal Administration
^[1]^[2]

Rats: Nephrocalcinosis in 6-week-old male Wistar rats is induced by continuous injection of rat PTH 1-34 at a dosage of 40 μg/kg per day via an osmotic mini-pump for 50 hours. L-lysine HCl or glycine at a dose of 20 mmol/kg is administered via a gastric tube at 2 hours, 14 hours, 26 hours, and 38 hours after the implantation of the osmotic pump. At the indicated periods, Serum and urinary biochemical parameters, urea nitrogen, albumin, calcium, inorganic phosphate, and magnesium are determined by clinical diagnostic reagents^[2].

Mice: Four groups of mice (10 in each group) are assessed. Group I is the control. Animals in groups II-IV are injected intraperitoneally with L-arginine hydrochloride (400 mg/kg body weight [bw]) for 3 days. Group III animals are orally pre-treated with L-lysine(10 mg/kg bw), whereas group IV animals are orally post-treated with L-lysine(10 mg/kg bw). Serum samples are subjected to amylase, lipase, transaminase, and interleukin-6 (IL-6) assays. The pancreas is excised to measure the levels of malondialdehyde, nitric oxide, catalase, superoxide dismutase, reduced glutathione, and glutathione peroxidase^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [Content Brief]

[2]. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009. [Content Brief]

[3]. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.4750 mL	27.3748 mL	54.7495 mL	136.8738 mL
	5 mM	1.0950 mL	5.4750 mL	10.9499 mL	27.3748 mL
	10 mM	0.5475 mL	2.7375 mL	5.4750 mL	13.6874 mL
	15 mM	0.3650 mL	1.8250 mL	3.6500 mL	9.1249 mL
	20 mM	0.2737 mL	1.3687 mL	2.7375 mL	6.8437 mL
	25 mM	0.2190 mL	1.0950 mL	2.1900 mL	5.4750 mL
	30 mM	0.1825 mL	0.9125 mL	1.8250 mL	4.5625 mL
	40 mM	0.1369 mL	0.6844 mL	1.3687 mL	3.4218 mL
	50 mM	0.1095 mL	0.5475 mL	1.0950 mL	2.7375 mL
	60 mM	0.0912 mL	0.4562 mL	0.9125 mL	2.2812 mL
	80 mM	0.0684 mL	0.3422 mL	0.6844 mL	1.7109 mL
	100 mM	0.0547 mL	0.2737 mL	0.5475 mL	1.3687 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.