2. Anti-infection Metabolic Enzyme/Protease
  3. Virus Protease Endogenous Metabolite
  4. L-Lysine hydrochloride

L-リジン塩酸塩  (Synonyms: L-Lysine hydrochloride)

製品番号: HY-N0470 純度: 98.0%
COA 取扱説明書 Technical Support

L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 657-27-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
1 g $25 在庫あり
5 g $35 在庫あり
10 g $42 在庫あり
25 g $55 在庫あり
50 g $66 在庫あり
100 g $77 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Other Forms of L-Lysine hydrochloride:

L-リジン塩酸塩 関連抗体

Top Publications Citing Use of Products

    L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Serum FITC-dextran levels were reduced upon L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation, indicating improved barrier function. L-Lysine also partially reversed the weight loss.

    L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Representative immunofluorescence images of ZO-1 and red mean density analysis of ZO-1 in the ileum and colon. L-Lysine (200 mg/kg; once daily; i.g.; 7 d) supplementation significantly restored ZO-1 density.

    L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Effect of L-Lysine (1.4 mM; 12 h) intervention on the scratch injury healing rate of IFN-γ pre-processed and NCM-460 cells. IFN‐γ significantly impaired healing in NCM-460 cells, and this effect was significantly alleviated by L‐Lysine.

    L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    Effects of L-Lysine (1.4 mM; 24 h) intervention on the ZO-1 and Occludin expression of IFN-γ pre-processed HIEC-6 cells by western blot.

    L-Lysine hydrochloride purchased from MedChemExpress. Usage Cited in: iMetaOmics. 2025 Aug 06.

    L-Lysine (0.7-2.8 mM) dose-dependently inhibits H.biformis growth in vitro.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体内実験

    L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhances antioxidant activity. Pre- or post-treatment with L-lysine leads to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement is observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione[1]. L-lysine supplementation almost completely ameliorates vascular calcification. Dietary L-lysine strongly suppresses plasma intact parathyroid hormone in adenine rats and supports a proper bone-vascular axis. The conserved orientation of the femoral apatite in group Lys also evidences the bone-protective effects of L-lysine. Dietary L-lysine elevates plasma alanine, proline, arginine, and homoarginine but not lysine[2]. The dose-dependent delay in gastric emptying observed in rats is confirmed in humans with an increase in halftime of gastric emptying of 4 min/g L-lysine. Moreover, a dose-dependent increase in intestinal fluid accumulation is observed (0.4 mL/min/g L-lysine)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    182.65

    分子式

    C6H15ClN2O2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    N[C@@H](CCCCN)C(O)=O.[H]Cl
    Structure Classification
    Initial Source

    a genetically modified strain of Escherichia coli.
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Store at room temperature, keep dry and cool

    *In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (547.50 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.4750 mL 27.3748 mL 54.7495 mL
    5 mM 1.0950 mL 5.4750 mL 10.9499 mL
    10 mM 0.5475 mL 2.7375 mL 5.4750 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (273.75 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Dosing volume
    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: ≥98.0%

    COA (244 KB) HNMR (130 KB) LCMS (325 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [1][2]

    Rats: Nephrocalcinosis in 6-week-old male Wistar rats is induced by continuous injection of rat PTH 1-34 at a dosage of 40 μg/kg per day via an osmotic mini-pump for 50 hours. L-lysine HCl or glycine at a dose of 20 mmol/kg is administered via a gastric tube at 2 hours, 14 hours, 26 hours, and 38 hours after the implantation of the osmotic pump. At the indicated periods, Serum and urinary biochemical parameters, urea nitrogen, albumin, calcium, inorganic phosphate, and magnesium are determined by clinical diagnostic reagents[2].

    Mice: Four groups of mice (10 in each group) are assessed. Group I is the control. Animals in groups II-IV are injected intraperitoneally with L-arginine hydrochloride (400 mg/kg body weight [bw]) for 3 days. Group III animals are orally pre-treated with L-lysine(10 mg/kg bw), whereas group IV animals are orally post-treated with L-lysine(10 mg/kg bw). Serum samples are subjected to amylase, lipase, transaminase, and interleukin-6 (IL-6) assays. The pancreas is excised to measure the levels of malondialdehyde, nitric oxide, catalase, superoxide dismutase, reduced glutathione, and glutathione peroxidase[1].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.4750 mL 27.3748 mL 54.7495 mL 136.8738 mL
    5 mM 1.0950 mL 5.4750 mL 10.9499 mL 27.3748 mL
    10 mM 0.5475 mL 2.7375 mL 5.4750 mL 13.6874 mL
    15 mM 0.3650 mL 1.8250 mL 3.6500 mL 9.1249 mL
    20 mM 0.2737 mL 1.3687 mL 2.7375 mL 6.8437 mL
    25 mM 0.2190 mL 1.0950 mL 2.1900 mL 5.4750 mL
    30 mM 0.1825 mL 0.9125 mL 1.8250 mL 4.5625 mL
    40 mM 0.1369 mL 0.6844 mL 1.3687 mL 3.4218 mL
    50 mM 0.1095 mL 0.5475 mL 1.0950 mL 2.7375 mL
    60 mM 0.0912 mL 0.4562 mL 0.9125 mL 2.2812 mL
    80 mM 0.0684 mL 0.3422 mL 0.6844 mL 1.7109 mL
    100 mM 0.0547 mL 0.2737 mL 0.5475 mL 1.3687 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Lysine hydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Lysine657-27-2Virus ProteaseEndogenous MetaboliteInhibitorinhibitorinhibit

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