2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P991471
    GB-0895
    GB-0895 is a human monoclonal antibody (mAb) targeting TSLP. GB-0895 can be used in Asthma research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    GB-0895
  • HY-W002116
    Methyl syringate 884-35-5
    Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis.
    Methyl syringate
  • HY-W003969
    Aminopicoline 695-34-1 ≥98.0%
    Aminopicoline (Ascensil) is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes (iNOS, nNOS, eNOS). Aminopicoline competes with arginine at the substrate-binding site of nitric oxide synthase, reduces cellular nitric oxide production, inhibits the elevation of plasma nitrate, increases mean arterial pressure at high doses, and also serves as a basis for radiolabeled ligands to localize nitric oxide synthase binding sites. Aminopicoline can be used in the research of diseases associated with septic shock, joint inflammation, intestinal inflammation, and CNS inflammation.
    Aminopicoline
  • HY-W008956
    Myoseverin 267402-71-1 99.17%
    Myoseverin is a microtubule-binding molecule and angiogenesis inhibitor. Myoseverin can induce the reversible fission of multinucleated myotubes into mononucleated fragments. In addition, Myoseverin exerts anti-angiogenic effects by inhibiting endothelial cell function and endothelial progenitor cell differentiation.
    Myoseverin
  • HY-W009248
    Phenethyl ferulate 71835-85-3 99.66%
    Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 4.35 μM and 5.75 μM, respectively.
    Phenethyl ferulate
  • HY-W012817
    Methylhydroquinone 95-71-6 99.91%
    Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions.
    Methylhydroquinone
  • HY-W013675
    2-Methoxyhydroquinone 824-46-4 99.57%
    2-Methoxyhydroquinone is a phenolic compound that reduces TNF-α-induced production of chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. 2-Methoxyhydroquinone is also a precursor in the synthesis of the Hsp90 inhibitor Geldanamycin (HY-15230).
    2-Methoxyhydroquinone
  • HY-W039116
    Thalidomide-4-Br 2093536-12-8
    Thalidomide-4-Br (compound 53) is a compound with a bromodomain. Thalidomide-4-Br can be used in the research of inflammation, tumor and neurology.
    Thalidomide-4-Br
  • HY-W040255
    1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine 89947-79-5 99.9%
    1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis-related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis.
    1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine
  • HY-W041193
    3-Hydroxy-2-pyrone 496-64-0
    3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation.
    3-Hydroxy-2-pyrone
  • HY-W176629
    Hydrocotarnine 550-10-7 99.70%
    Hydrocotarnine is a Cbl inhibitor, and results in inflammasome-mediated IL-18 secretion in colitis. Hydrocotarnine increases expression of GLUT1 and cellular glucose uptake in glycolytic metabolism. Hydrocotarnine acts as an agent that provides analgesic effect in cancer research.
    Hydrocotarnine
  • HY-W184800
    MuRF1-IN-2 937891-74-2 99.05%
    MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor. MuRF1-IN-2 can be used for research of muscle wasting conditions, of skeletal or cardial muscle atrophy.
    MuRF1-IN-2
  • HY-Y0850U6
    PVA (Mw 205000) 9002-89-5
    PVA (Polyvinyl alcohol) (Mw 205000) is a polyvinyl alcohol with a molecular weight of 205000, which is used as a biological additive. PVA (Mw 205000) can be cross-linked through physical or chemical methods to form hydrogels, and is widely applied in fields such as biomedicine, food packaging, textiles, papermaking, sensing, and electronic devices. After PVA enema, it has an improving effect on acute colitis induced by DSS (HY-116282C) in mice.
    PVA (Mw 205000)
  • HY-W017443S
    L-Asparagine-13C4,15N2 monohydrate 202406-87-9 98.0%
    L-Asparagine-13C4,15N2 monohydrateis the 13C-labeled and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-13C4,15N2 monohydrate
  • HY-W018772S15
    D-Ribose(mixture of isomers)-13C5 202114-47-4 99.95%
    D-Ribose(mixture of isomers)-13C5 isomers)-13C5 is the 13C labeled D-Ribose(mixture of isomers). D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner.
    D-Ribose(mixture of isomers)-13C5
  • HY-44178
    Diethyl butylmalonate 133-08-4 ≥98.0%
    Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC50-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease.
    Diethyl butylmalonate
  • HY-B0289
    Erdosteine 84611-23-4 99.54%
    Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects.
    Erdosteine
  • HY-N2736
    3′,4′,7-Trihydroxyflavone 2150-11-0 99.04%
    3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 μM) and COX-1 (IC50 = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice.
    3′,4′,7-Trihydroxyflavone
  • HY-N9493
    Chrysanthemol 5617-92-5 99.02%
    Chrysanthemol is a eudesmane type sesquiterpene that can be isolated from Chrysanthemum indicum. Chrysanthemol has anti-inflammatory activity.
    Chrysanthemol
  • HY-112026
    1-Adamantaneethanol 6240-11-5 ≥98.0%
    1-Adamantaneethanol, a hapten, influences peptide binding by MHC II.
    1-Adamantaneethanol
Cat. No. Product Name / Synonyms Application Reactivity