Aryl Hydrocarbon Receptor Agonist

L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a K_d of 70 pM.

Indole-3-pyruvic acid is an orally active ketone analog of tryptophan, and is an aryl hydrocarbon receptor (AHR) agonist. Indole-3-pyruvic acid inhibits p38/MAPK phosphorylation, regulates the tryptophan metabolic pathway, and also possesses protective activities against skin photodamage, as well as anti-inflammatory and anti-anxiety bioactivities in the gut. Indole-3-pyruvic acid can downregulate the expression of IL-1β, IL-6, Cox-2, and Bax to alleviate UVB-induced keratinocyte toxicity. Indole-3-pyruvic acid can activate AHR to promote Tr1 cell differentiation, increase IL-10, and inhibit Th1 cytokine production. Indole-3-pyruvic acid can alter the levels of kynurenine metabolites in the brain, mediating central nervous system-related effects. Indole-3-pyruvic acid can be used in research on skin lesions, colitis, and anxiety.

β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to study aristolochic acid (AAI) induced renal injury.

Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC₅₀ of 13 nM. Tapinarof resolves skin inflammation in mice.

Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a K_i of 3 nM. ITE also has immunosuppressive activity.

Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases.

L-Kynurenine (Standard) is the analytical standard of L-Kynurenine. This product is intended for research and analytical applications. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.

L-Kynurenine-d₄ is the deuterium labeled L-Kynurenine. L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist[1][2].

D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR).

1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis.

MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist, with IC₅₀ of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively.

VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14⁺CD11b⁺ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.

25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1.

Indole-3-pyruvic acid (Standard) is the analytical standard of Indole-3-pyruvic acid (HY-W028393). This product is intended for research and analytical applications. Indole-3-pyruvic acid is an orally active ketone analog of tryptophan, and is an aryl hydrocarbon receptor (AHR) agonist. Indole-3-pyruvic acid inhibits p38/MAPK phosphorylation, regulates the tryptophan metabolic pathway, and also possesses protective activities against skin photodamage, as well as anti-inflammatory and anti-anxiety bioactivities in the gut. Indole-3-pyruvic acid can downregulate the expression of IL-1β, IL-6, Cox-2, and Bax to alleviate UVB-induced keratinocyte toxicity. Indole-3-pyruvic acid can activate AHR to promote Tr1 cell differentiation, increase IL-10, and inhibit Th1 cytokine production. Indole-3-pyruvic acid can alter the levels of kynurenine metabolites in the brain, mediating central nervous system-related effects. Indole-3-pyruvic acid can be used in research on skin lesions, colitis, and anxiety.

Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.

10-Cl-BBQ is a high affinity AhR ligand with immunosuppressive activity. 10-Cl-BBQ promotes cytosol to nuclear translocation of AhR and activates the AhR-regulated reporter gene at nanomolar concentrations.