25-Hydroxytachysterol3
Based on 1 Customer Validation
25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1.
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- Pureza : 98.07%
- No. CAS: 39932-44-0
- Fòrmula: C27H44O2
- Peso molecular:400.64
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Almacenamiento:Shipping with dry ice
-80°C, protect from light, stored under nitrogen
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Actividad biológica
Descripciòn
IC50 & Target
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PPARγ |
In Vitro
25-Hydroxytachysterol3 (25(OH)T3) (0.1-100 μM; 24-48 h) inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts[1].
25-Hydroxytachysterol3 (0.1-100 μM; 24 h) stimulates the expression of genes involved in keratinocyte differentiation and antioxidative pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary human epidermal keratinocytes or dermal fibroblasts.
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Concentration:0.1 μM, 1 μM, 10 μM, 100 μM
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Incubation Time:24 h or 48 h
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Result:Inhibited the proliferation of epidermal keratinocytes and dermal fibroblasts.
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Cell Line:Primary human epidermal keratinocytes or dermal fibroblasts.
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Concentration:0.1 μM, 1 μM, 10 μM, 100 μM
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Incubation Time:24 h
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Result:Showed stimulation of the expression of genes involved in keratinocyte differentiation (KRT1, KRT10, FLG, IVL, LOR, TGM1) and antioxidative pathways (CAT, SOD1, SOD2).
Chemical Information
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No. CAS 39932-44-0
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Appearance Solid
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Peso molecular 400.64
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Fòrmula C27H44O2
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])C(/C=C/C3=C(CC[C@@H](C3)O)C)=CCC1
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Envío
Shipping with dry ice.
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Almacenamiento
-80°C, protect from light, stored under nitrogen
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
25-Hydroxytachysterol3 Related Classifications
HY-77278 Related Classifications
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