H₁ Receptor Antagonist

H₁ Receptor Antagonists (51):

Cat. No.	Product Name	Effect	Purity

HY-B0298A

Clemastine fumarate	Antagonist	99.95%
Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist.

HY-B1193

Terfenadine	Antagonist	99.91%
Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC₅₀ of 204 nM.

HY-12532

Astemizole	Antagonist	99.62%
Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM.

HY-B0801A

Fexofenadine hydrochloride	Antagonist	99.70%
Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H₁ receptor antagonist.

HY-148825

NP10679	Antagonist
NP10679 is a selective, pH dependent GluN2B subunit-specific N-methyl-D-aspartate (NMDA) receptor inhibitor with high oral bioavailability and good brain penetration.

HY-B0539

Desloratadine	Antagonist	99.83%
Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine.

HY-B0725

Doxepin Hydrochloride	Antagonist	99.84%
Doxepin hydrochloride is an orally active tricyclic antidepressant agent.

HY-B0781

Promethazine hydrochloride	Antagonist	≥98.0%
Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.

HY-B0303A

Diphenhydramine hydrochloride	Antagonist	99.90%
Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect.

HY-B0352

Mirtazapine	Antagonist	99.08%
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent.

HY-B0674

Ebastine	Antagonist	99.54%
Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist.

HY-13511A

Rupatadine Fumarate	Antagonist	98.77%
Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with K_is of 0.55 μM and 0.1 μM, respectively.

HY-B0462

Azelastine hydrochloride	Antagonist	99.93%
Azelastine hydrochloridem, an antihistamine, is a potent and selective histamine 1 (H₁) antagonist.

HY-B0274

Chlorprothixene	Antagonist	99.13%
Chlorprothixene is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.

HY-123205

Oxatomide	Antagonist	99.47%
Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity.

HY-10121

Asenapine	Antagonist	99.93%
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0).

HY-107647

(S)-(+)-Dimethindene maleate	Antagonist	99.94%
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M₂-selective muscarinic receptor antagonist (pA₂ = 7.86/7.74; pK_i = 7.78).

HY-B0274A

Chlorprothixene hydrochloride	Antagonist	≥98.0%
Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with K_is of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively.

HY-121356

Carebastine	Antagonist	99.12%
Carebastine is the active metabolite of Ebastine.

HY-101232

Tiotidine	Antagonist	99.28%
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA₂=7.3-7.8 for guinea-pig right atrium).

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