1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Diphenhydramine hydrochloride (Synonyms: DPH)

Cat. No.: HY-B0303A Purity: 99.75%
Handling Instructions

Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations.

For research use only. We do not sell to patients.

Diphenhydramine hydrochloride Chemical Structure

Diphenhydramine hydrochloride Chemical Structure

CAS No. : 147-24-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
250 mg USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
500 mg USD 72 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 g USD 96 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. Target: Histamine H1 receptor Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. Diphenhydramine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.4268 mL 17.1338 mL 34.2677 mL
5 mM 0.6854 mL 3.4268 mL 6.8535 mL
10 mM 0.3427 mL 1.7134 mL 3.4268 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

291.82

Formula

C₁₇H₂₂ClNO

CAS No.

147-24-0

SMILES

CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 18 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Diphenhydramine hydrochloride
Cat. No.:
HY-B0303A
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