1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
    Membrane Transporter/Ion Channel
  2. Histamine Receptor
    P2X Receptor
    5-HT Receptor
  3. Oxatomide

Oxatomide 

Cat. No.: HY-123205 Purity: 99.47%
Handling Instructions

Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.

For research use only. We do not sell to patients.

Oxatomide Chemical Structure

Oxatomide Chemical Structure

CAS No. : 60607-34-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin[1][2].

IC50 & Target

H1 Receptor

 

P2X7

 

serotonin

 

Clinical Trial
Molecular Weight

426.55

Formula

C₂₇H₃₀N₄O

CAS No.

60607-34-3

SMILES

O=C1NC2=CC=CC=C2N1CCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (586.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3444 mL 11.7220 mL 23.4439 mL
5 mM 0.4689 mL 2.3444 mL 4.6888 mL
10 mM 0.2344 mL 1.1722 mL 2.3444 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OxatomideHistamine ReceptorP2X Receptor5-HT ReceptorP2XRsSerotonin Receptor5-hydroxytryptamine ReceptorP2X7anti-allergicantihistamineATPCa2+serotoninH1-histamineInhibitorinhibitorinhibit

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Oxatomide
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HY-123205
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