1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
    Metabolic Enzyme/Protease
  2. Histamine Receptor
    Cytochrome P450
  3. Doxepin Hydrochloride

Doxepin Hydrochloride 

Cat. No.: HY-B0725 Purity: 99.84%
COA Handling Instructions

Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant.
. Doxepin has therapeutic effects in atopic dermatitis,chronic urticarial,can improve cognitive processes, protect central nervous system.
. Doxepin has also been proposed as a protective factor against oxidative stress.
.

For research use only. We do not sell to patients.

Doxepin Hydrochloride Chemical Structure

Doxepin Hydrochloride Chemical Structure

CAS No. : 1229-29-4

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Solid
500 mg USD 50 In-stock
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1 g USD 60 In-stock
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5 g USD 156 In-stock
Estimated Time of Arrival: December 31
10 g USD 192 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Doxepin Hydrochloride:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2]. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant[3].
. Doxepin has therapeutic effects in atopic dermatitis,chronic urticarial,can improve cognitive processes, protect central nervous system[4].
. Doxepin has also been proposed as a protective factor against oxidative stress[5].
.

In Vitro

The protective effect of doxepin is associated with the enhancement of PSD-95 and synapsin 1 expression via PI3K/AKT/mTOR signaling pathway[6].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line: SH-SY5Y human neuroblastoma cell line
Concentration: 10 ng/ml
Incubation Time: 2 h
Result: Improved the protein expre-ssion levels of PSD-95, synapsin 1 and p-AKT in SH-SY5Y cells, and decreased the protein expression level of p-mTOR in SH-SY5Y cells.
In Vivo

Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days) can protect against the Aβ1-42-induced memory impairment in rats[6].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD male rats[6].
Dosage: 1, 5mg/kg
Administration: Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days)
Result: Improved the protein expression levels of PSD-95 and synapsin 1 in hippocampus and tem-poral lobe, and decreased the protein expression level of p-AKT in hippocampus and temporal lobe after treatment of 1 mg/kg of doxepin.
Clinical Trial
Molecular Weight

315.84

Formula

C19H22ClNO

CAS No.
SMILES

CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (316.62 mM)

H2O : ≥ 50 mg/mL (158.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1662 mL 15.8308 mL 31.6616 mL
5 mM 0.6332 mL 3.1662 mL 6.3323 mL
10 mM 0.3166 mL 1.5831 mL 3.1662 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 140 mg/mL (443.26 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.92 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.92 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Doxepin Hydrochloride
Cat. No.:
HY-B0725
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