2. Doxepin

Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress.

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Doxepin Chemical Structure

Doxepin Chemical Structure

CAS No. : 1668-19-5

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Doxepin Related Antibodies

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Description

Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress[1][2][3].

In Vitro

The protective effect of doxepin is associated with the enhancement of PSD-95 and synapsin 1 expression via PI3K/AKT/mTOR signaling pathway[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Doxepin Related Antibodies

Western Blot Analysis[4]

Cell Line: SH-SY5Y human neuroblastoma cell line
Concentration: 10 ng/mL
Incubation Time: 2 h
Result: Improved the protein expre-ssion levels of PSD-95, synapsin 1 and p-AKT in SH-SY5Y cells, and decreased the protein expression level of p-mTOR in SH-SY5Y cells.
In Vivo

Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days) can protect against the Aβ1-42-induced memory impairment in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD male rats[4]
Dosage: 1, 5mg/kg
Administration: Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days)
Result: Improved the protein expression levels of PSD-95 and synapsin 1 in hippocampus and tem-poral lobe, and decreased the protein expression level of p-AKT in hippocampus and temporal lobe after treatment of 1 mg/kg of doxepin.
Clinical Trial
Molecular Weight

279.38

Formula

C19H21NO
CAS No.
SMILES

CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13
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Purity & Documentation
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  • Do most proteins show cross-species activity?

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Keywords:

Doxepin1668-19-5Inhibitorinhibitorinhibit

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