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Cat. No.: HY-B0725S

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Doxepin-d₃ hydrochloride

Name: Doxepin-d3 hydrochloride
Brand: MedChemExpress
SKU: HY-B0725S
Price: 150.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Doxepin-d₃ hydrochloride is the deuterated-labeled Doxepin Hydrochloride (HY-B0725). Doxepin Hydrochloride is an orally active tricyclic antidepressant capable of crossing the blood-brain barrier. Doxepin Hydrochloride enhances the expression of PSD-95 and synapsin-1 via the PI3K/AKT/mTOR signaling pathway and is metabolized in vivo into Desmethyldoxepin Hydrochloride (Nordoxepin hydrochloride) (HY-100046). Doxepin Hydrochloride binds to the serotonin transporter (SERT) and the norepinephrine transporter (NET), with K_d values of 68 nM and 29.5 nM, respectively. Doxepin Hydrochloride can be used in research concerning various conditions, including depression, anxiety, obesity, and atopic dermatitis.

For research use only. We do not sell to patients.

Purity : 99.60%
CAS No.: 347840-07-7
Formula: C₁₉H₁₉D₃ClNO
Molecular Weight:318.86

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Doxepin-d₃ hydrochloride Chemical Structure

CAS No.: 347840-07-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-B0847S
Propiconazole-d7

Stable Isotope

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]^[2]^[3]^[4]^[5]

Akt

mTOR

PSD-95

SERT

68 nM (Kd)

NET

29.5 nM (Kd)

All Akt Isoforms :

All mTOR Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 347840-07-7
Unlabeled CAS 1229-29-4
Appearance Solid
Molecular Weight 318.86
Formula C₁₉H₁₉D₃ClNO
Color Off-white to light yellow
SMILES

[2H]C(N(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C\13)([2H])[2H].[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (293 KB)
SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bu J. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20(9):1044-1049. [Content Brief]

[2]. Pinder R M, et al. Doxepin Up-to-Date: A Review of its Pharmacological Properties and Therapeutic Efficacy with Particular Reference to Depression. Drugs, 1977, 13: 161-218.

[3]. Chang GR, et al. Doxepin Exacerbates Renal Damage, Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Urinary Chromium Loss in Obese Mice. Pharmaceuticals (Basel, Switzerland). 2021 Mar 16;14(3):267.

[4]. Sun XY, et al. Characterization of the anticonvulsant activity of doxepin in various experimental seizure models in mice. Pharmacological reports : PR. 2009;61(2):245-51.

[5]. Tatsumi M, et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References

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Doxepin-d₃ hydrochloride

All Akt Isoforms

All mTOR Isoforms